{"id":13382,"date":"1970-01-01T01:00:00","date_gmt":"1970-01-01T00:00:00","guid":{"rendered":"http:\/\/univet.hu\/egyetem\/szervezeti-egysegek\/bioinformatikai-kozpont\/bioinformatikai-kutatocsoport\/"},"modified":"2023-09-19T14:50:48","modified_gmt":"2023-09-19T12:50:48","slug":"forschungsgruppe-bioinformatik","status":"publish","type":"page","link":"https:\/\/univet.hu\/de\/universitaet\/organisationseinheiten\/zentrum-fur-bioinformatik\/forschungsgruppe-bioinformatik\/","title":{"rendered":"Forschungsgruppe Bioinformatik"},"content":{"rendered":"<p><strong>Universit\u00e4t f\u00fcr Veterin\u00e4rmedizin Budapest<\/strong><\/p> <p><strong>Forschungsgruppe Bioinformatik<\/strong><\/p> <p><strong>FORSCHUNGSGRUPPENLEITER: Norbert Solymosi<\/strong><\/p> <p><strong>KONTAKT: <\/strong><a class=\"decrypt\" rel=\"tpmznptj\/opscfsuAvojwfu\/iv\" href=\"javascript:void(0);\">[Click to see email]<\/a><\/p> <p><strong>MITGLIEDER DER FORSCHUNGSGRUPPE:<\/strong><\/p> <p>Ordentlicher Professor: Istv\u00e1n Csabai (Abteilung f\u00fcr Physik komplexer Systeme), R\u00f3bert Farkas, Zolt\u00e1n Sz\u00e1ll\u00e1si (Computational Health Informatics Program (CHIP), Boston Children\u2019s Hospital, Boston, MA, USA)<\/p> <p>Au\u00dferordentlicher Professor: L\u00e1szl\u00f3 Makrai, Norbert Solymosi<\/p> <p>Leitender Dozent: \u00c1kos Mar\u00f3ti-Ag\u00f3ts<\/p> <p>Wissenschaftlicher Mitarbeiter: S\u00e1ndor Spis\u00e1k (Harvard Medical School, Dana Farber Cancer Institute, Abteilung f\u00fcr Medizinische Onkologie), G\u00e1bor Valcz (Labor f\u00fcr Molekulare Gastroenterologie, 2. Abteilung f\u00fcr Innere Medizin, Semmelweis-Universit\u00e4t)<\/p> <p>Assistent: &#8211;<\/p> <p>Doktorand: Andr\u00e1s Adorj\u00e1n<\/p> <p><strong>FORSCHUNGSGEBIETE:<\/strong><\/p> <p>Wir arbeiten an der Verarbeitung und Analyse von Datens\u00e4tzen, die durch bioinformatische Technologien mit unterschiedlichem Durchsatz generiert werden. Durch die digitale Bildanalyse unterst\u00fctzen wir Forschungen in der quantitativen Bakteorologie und Pathologie. Basierend auf Genexpressions-Microarray-Datens\u00e4tzen f\u00fchren wir Biomarker-Identifizierung und systembiologische Analysen durch. F\u00fcr verschiedene Forschungszwecke (z. B. Mikrobiom, Polymorphismus, Methylierungsmuster) f\u00fchren wir Sequenzierungsdatenanalysen der n\u00e4chsten Generation durch.<\/p> <p><strong>MITGLIEDSCHAFTEN:<\/strong><\/p> <p><strong>LANGFRISTIGE ZUSAMMENARBEIT:<\/strong><\/p> <ul> <li>Abteilung f\u00fcr endokrine Neurobiologie, Institut f\u00fcr experimentelle Medizin der Ungarischen Akademie der Wissenschaften<\/li> <li>Abteilung f\u00fcr Physik komplexer Systeme, E\u00f6tv\u00f6s-L\u00f3r\u00e1nd-Universit\u00e4t<\/li> <li>II. Abteilung f\u00fcr Innere Medizin und Klinik, Labor f\u00fcr Molekulare Gastroenterologie, Semmelweis-Universit\u00e4t<\/li> <li>Harvard Medical School, Dana Farber Cancer Institute, Medizinische Onkologie<\/li> <\/ul> <p>DIENSTLEISTUNGEN:<\/p> <ul> <li>quantitative digitale Bildanalyse<\/li> <li>Analyse von Genexpressions-Microarray-Daten<\/li> <li>Analyse von NGS-Daten<\/li> <\/ul> <p>&nbsp;<\/p> <p><strong>ZUSCH\u00dcSSE: &#8211;<\/strong><\/p> <p>&nbsp;<\/p> <table border=\"1\" cellspacing=\"0\" cellpadding=\"0\"> <tbody> <tr> <td style=\"height: 63px; width: 128px;\"><strong>Name der unterst\u00fctzenden Organisation\/Quelle<\/strong><\/td> <td style=\"height: 63px; width: 345px;\"><strong>Titel und Thema des Ausschreibungsprojekts (kurz)<\/strong><\/td> <td style=\"height: 63px; width: 128px;\"><strong>Zuschussbetrag (in HUF)<\/strong><\/td> <\/tr> <tr> <td style=\"height: 63px; width: 128px;\">EU H2020<\/td> <td style=\"height: 63px; width: 345px;\">COMPARE ist ein multidisziplin\u00e4res Forschungsnetzwerk mit der gemeinsamen Vision, ein analytischer Rahmen und eine weltweit vernetzte Daten- und Informationsaustauschplattform f\u00fcr die schnelle Identifizierung, Eind\u00e4mmung und Eind\u00e4mmung neu auftretender Infektionskrankheiten und lebensmittelbedingter Ausbr\u00fcche zu werden. (<a href=\"http:\/\/www.compare-europe.eu\">http:\/\/www.compare-europe.eu<\/a>\/)<\/td> <td style=\"height: 63px; width: 128px;\">6400,000,000 (20000000 \u20ac)<\/td> <\/tr> <\/tbody> <\/table> <p>&nbsp;<\/p> <p><strong>VERTR\u00c4GE: &#8211;<\/strong><\/p> <p><strong>Weitere Informationen zu den Forschungsdienstleistungen<\/strong><\/p> <p>&nbsp;<\/p> <p><strong>Bisher erzielte Ergebnisse, Darstellung relevanter Referenzen (F\u00f6rderungen und Vertr\u00e4ge)<\/strong><\/p> <ul> <li>Bodor A, Csabai I, Mahoney M W, Solymosi N. rCUR: an R package for CUR matrix decomposition. BMC BIOINFORMATICS 13:(1) Paper 103. 6 p. (2012)<\/li> <li>Galamb O, Gy\u0151rffy B, Sipos F, Dinya E, Kren\u00e1cs T, Berczi L, Sz\u0151ke D, Spis\u00e1k S, Solymosi N, N\u00e9meth AM, Juh\u00e1sz M, Moln\u00e1r B, Tulassay Z. Helicobacter pylori and antrum erosion-specific gene expression patterns: The discriminative role of CXCL13 and VCAM1 transcripts. HELICOBACTER 13:(2) pp. 112-126. (2008)<\/li> <li>Galamb O, Sipos F, Solymosi N, Spis\u00e1k S, Kren\u00e1cs T, T\u00f3th K, Tulassay ZS, Moln\u00e1r B. Diagnostic mRNA expression patterns of inflamed, benign, and malignant colorectal biopsy specimen and their correlation with peripheral blood results. CANCER EPIDEMIOLOGY BIOMARKERS &amp; PREVENTION 17:(10) pp. 2835-2845. (2008)<\/li> <li>Galamb O, Spis\u00e1k S, Sipos F, T\u00f3th K, Solymosi N, Wichmann B, Kren\u00e1cs T, Valcz G, Tulassay ZS, Moln\u00e1r B. Reversal of gene expression changes in the colorectal normal-adenoma pathway by NS398 selective COX2 inhibitor. BRITISH JOURNAL OF CANCER 102:(4) pp. 765-773. (2010)<\/li> <li>Jalan S, Solymosi N, Vattay G, Li BW. Random matrix analysis of localization properties of gene coexpression network. PHYSICAL REVIEW E &#8211; STATISTICAL, NONLINEAR AND SOFT MATTER PHYSICS 81:(4) p. 046118. (2010)<\/li> <li>S\u00e1rv\u00e1ri M, Hrabovszky E, Kall\u00f3 I, Galamb O, Solymosi N, Liko I, Moln\u00e1r B, Tihanyi K, Szombathelyi Z, Liposits Z. Gene expression profiling identifies key estradiol targets in the frontal cortex of the rat. ENDOCRINOLOGY 151:(3) pp. 1161-1176. (2010)<\/li> <li>S\u00e1rv\u00e1ri M, Hrabovszky E, Kall\u00f3 I, Solymosi N, Liko I, Berchtold N, Cotman C, Liposits Z. Menopause leads to elevated expression of macrophage-associated genes in the aging frontal cortex: rat and human studies identify strikingly similar changes. JOURNAL OF NEUROINFLAMMATION 9:(1) p. 264. (2012)<\/li> <li>S\u00e1rv\u00e1ri M, Hrabovszky E, Kall\u00f3 I, Solymosi N, T\u00f3th K, Liko I, Szeles J, Maho S, Moln\u00e1r B, Liposits Z. Estrogens regulate neuroinflammatory genes via estrogen receptors alpha and beta in the frontal cortex of middle-aged female rats. JOURNAL OF NEUROINFLAMMATION 8:(1) p. 82. (2011)<\/li> <li>S\u00e1rv\u00e1ri M, Kall\u00f3 I, Hrabovszky E, Solymosi N, Liposits Z. Ovariectomy Alters Gene Expression of the Hippocampal Formation in Middle-Aged Rats. ENDOCRINOLOGY (k\u00f6zl\u00e9sre elfogadva) (2016)<\/li> <li>S\u00e1rv\u00e1ri M, Kall\u00f3 I, Hrabovszky E, Solymosi N, Liposits Z. Ovariectomy and subsequent treatment with estrogen receptor agonists tune the innate immune system of the hippocampus in middle-aged female rats. PLOS ONE 9:(2) p. e88540. (2014)<\/li> <li>S\u00e1rv\u00e1ri M, Kall\u00f3 I, Hrabovszky E, Solymosi N, Rodolosse A, Liposits Z. Long-Term Estrogen Receptor Beta Agonist Treatment Modifies the Hippocampal Transcriptome in Middle-Aged Ovariectomized Rats. FRONTIERS IN CELLULAR NEUROSCIENCE 10: p. 149. (2016)<\/li> <li>S\u00e1rv\u00e1ri M, Kall\u00f3 I, Hrabovszky E, Solymosi N, Rodolosse A, Vastagh C, Auer H, Liposits Z. Hippocampal Gene Expression Is Highly Responsive to Estradiol Replacement in Middle-Aged Female Rats. ENDOCRINOLOGY 156:(7) pp. 2632-2645. (2015)<\/li> <li>S\u00e1rv\u00e1ri M, Kall\u00f3 I, Hrabovszky E, Solymosi N, T\u00f3th K, Liko I, Moln\u00e1r B, Tihanyi K, Liposits Z. Estradiol Replacement Alters Expression of Genes Related to Neurotransmission and Immune Surveillance in the Frontal Cortex of Middle-Aged, Ovariectomized Rats. ENDOCRINOLOGY 151:(8) pp. 3847-3862. (2010)<\/li> <li>Spis\u00e1k S, Galamb B, Sipos F, Galamb O, Wichmann B, Solymosi N, Nemes B, Moln\u00e1r J, Tulassay ZS, Moln\u00e1r B. Applicability of antibody and mRNA expression microarrays for identifying diagnostic and progression markers of early and late stage colorectal cancer. DISEASE MARKERS 28:(1) pp. 1-14. (2010)<\/li> <li>Spis\u00e1k S\u00e1ndor, Kate Lawrenson, Yanfang Fu, Istv\u00e1n Csabai, Rebecca T Cottman, Ji-Heui Seo, Christopher Haiman, Ying Han, Romina Lenci, Qiyuan Li, Vikt\u00f3ria Tisza, Zolt\u00e1n Sz\u00e1ll\u00e1si, Zachery T Herbert, Matthew Chabot, Mark Pomerantz, Norbert Solymosi, The GAME-ON\/ELLIPSE Consortium, Simon A Gayther, J Keith Joung, Matthew L Freedman. CAUSEL: an epigenome- and genome-editing pipeline for establishing function of noncoding GWAS variants. NATURE MEDICINE 2015: pp. 1357-1363. (2015)<\/li> <li>Spis\u00e1k S\u00e1ndor, Solymosi Norbert, Ittz\u00e9s P\u00e9ter, Bodor Andr\u00e1s, Kondor D\u00e1niel, Vattay G\u00e1bor, Bart\u00e1k K Barbara, Sipos Ferenc, Galamb Orsolya, Tulassay Zsolt, Sz\u00e1ll\u00e1si Zolt\u00e1n, Rasmussen Simon, Sicheritz-Ponten Thomas, Brunak S\u00f6ren, Moln\u00e1r B\u00e9la, Csabai Istv\u00e1n. Complete genes may pass from food to human blood. PLOS ONE 8:(7) Paper e69805. 11 p. (2013)<\/li> <li>Sz\u0151ke D, Moln\u00e1r B, Solymosi N, Klausz G, Gyulai ZS, T\u00f3th B, M\u00e1ndi Y, Tulassay ZS. T251a polymorphism of il-8 relating to the development of histological gastritis and g-308a polymorphism of tnf-[alpha] relating to the development of macroscopic erosion. EUROPEAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 20:(3) pp. 191-196. (2008)<\/li> <li>Sz\u0151ke D, Moln\u00e1r B, Solymosi N, R\u00e1cz K, Gergics P, Blasko B, V\u00e1s\u00e1rhelyi B, Vannay A, M\u00e1ndy Y, Klausz G, Gyulai Zs, Galamb O, Spis\u00e1k S, Hutkai B, Somogyi A, Berta K, Szab\u00f3 A, Tulassay T, Tulassay Zs. Polymorphisms of the ApoE, HSD3B1, IL-1 beta and p53 genes are associated with the development of early uremic complications in diabetic patients: Results of a DNA resequencing array study. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 23:(2) pp. 217-227. (2009)<\/li> <li>Sz\u0151ke D, Moln\u00e1r B, Solymosi N, Sipos F, Galamb O, Gy\u0151rffy A, Tulassay Z. The RR genotype of codon 72 of p53 gene reduces the development of intestinal metaplasia. DIGESTIVE AND LIVER DISEASE 41:(3) pp. 179-184. (2009)<\/li> <li>Vastagh C, Rodolosse A, Solymosi N, Farkas I, Auer H, S\u00e1rv\u00e1ri M, Liposits Z. Differential Gene Expression in Gonadotropin-Releasing Hormone Neurons of Male and Metestrous Female Mice. NEUROENDOCRINOLOGY 102:(1-2) pp. 44-59. (2015)<\/li> <li>Vastagh C, Rodolosse A, Solymosi N, Liposits Z. Altered Expression of Genes Encoding Neurotransmitter Receptors in GnRH Neurons of Proestrous Mice. FRONTIERS IN CELLULAR NEUROSCIENCE 10: p. 230. (2016)<\/li> <\/ul> <p>&nbsp;<\/p>","protected":false},"excerpt":{"rendered":"<p>Universit\u00e4t f\u00fcr Veterin\u00e4rmedizin Budapest Forschungsgruppe Bioinformatik FORSCHUNGSGRUPPENLEITER: Norbert Solymosi KONTAKT: [Click to see email] MITGLIEDER DER FORSCHUNGSGRUPPE: Ordentlicher Professor: Istv\u00e1n Csabai (Abteilung f\u00fcr Physik komplexer Systeme), R\u00f3bert Farkas, Zolt\u00e1n Sz\u00e1ll\u00e1si (Computational Health Informatics Program (CHIP), Boston Children\u2019s Hospital, Boston, MA, USA) Au\u00dferordentlicher Professor: L\u00e1szl\u00f3 Makrai, Norbert Solymosi Leitender Dozent: \u00c1kos Mar\u00f3ti-Ag\u00f3ts Wissenschaftlicher Mitarbeiter: S\u00e1ndor Spis\u00e1k<\/p>\n","protected":false},"author":3837,"featured_media":0,"parent":3420,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"categories":[],"tags":[],"class_list":["post-13382","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/univet.hu\/de\/wp-json\/wp\/v2\/pages\/13382","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/univet.hu\/de\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/univet.hu\/de\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/univet.hu\/de\/wp-json\/wp\/v2\/users\/3837"}],"replies":[{"embeddable":true,"href":"https:\/\/univet.hu\/de\/wp-json\/wp\/v2\/comments?post=13382"}],"version-history":[{"count":0,"href":"https:\/\/univet.hu\/de\/wp-json\/wp\/v2\/pages\/13382\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/univet.hu\/de\/wp-json\/wp\/v2\/pages\/3420"}],"wp:attachment":[{"href":"https:\/\/univet.hu\/de\/wp-json\/wp\/v2\/media?parent=13382"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/univet.hu\/de\/wp-json\/wp\/v2\/categories?post=13382"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/univet.hu\/de\/wp-json\/wp\/v2\/tags?post=13382"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}