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Research Research teams Hepcidin Research Group

Hepcidin Research Group

RESEARCH GROUP LEADER: Dr. Zsuzsanna Vizi

CONTACT: vizi.zsuzsanna[PUT_AT_HERE]univet.hu

RESEARCH GROUP MEMBERS:

Professor: Dr. Péter Laczay (Department of Food Hygiene and Safity)

Associate professor:  Dr. Ágnes Sterczer

Associate research fellows: Dr. Zsuzsanna Vizi, Dr. Zsófia Aradi

Senior researcher: Dr. Katalin Lányi (Department of Food Hygiene and Safity)

Assistant: Katalin Mózes

RESEARCH AREAS:

Hepcidin (hepatic bactericid protein) is a 25-aminoacid peptide hormon, which is mainly produced in the liver and is the key regulator of the iron homeostasis. Hepcidin binds to the ferroportin causing its internalization and degradation. Through this blocking mechanism, it prevents the iron absorption from the duodenum and iron-outflow from macrophages causing hypoferraemia. Because of the low iron concentration in the blood, there is inefficient amount of iron for the erythropoesis in the bone marrow, causing non-regenerative anemia. The physiological reference values of this recently discovered hormone are not established yet and the clinical significance in the different diseases are not known. The goal of our study is to establish the reference range of the hepcidin in blood and urine in the healthy dogs. The following methods will be used in the research: ELISA and HPLC technics. Our other purpose is to measure the serum concentration of the hepcidin in the different diseases, mainly chronic diseases caused non regenerative anaemia and chronic liver diseases. We assume that the measurement of hepcidin level is an important diagnostic method in dogs as well in the clinical practice.

MEMBERSHIPS:

Society of Comparative Hepatology

Klinikus Állatorvosok Egyesülete
Magyar Kisállatgyógyász Állatorvosok Egyesülete
World Small Animal Veterinary Association

 

LONG-TERM COLLABORATIONS:

Dr. Balogh Nándor, PhD ECVP Praxislab Kft

 

SERVICES:

Hepcidin measurement in  dogs

 

GRANTS:

Funding source

Project title and topic

Amount (HUF)

Research Faculty

(Ministry of Human Capacities)

Detection of the hepcidin level in healthy dogs and in chronic non-regenerative anaemia (2016)

2.000.000

Research Faculty

(Ministry of Human Capacities)

Detection of the normal hepcidin level with HPLC method in healthy dogs (2013)

1.000.000