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Research Research teams Immunoendocrinology and Epigenetics Research Group

Immunoendocrinology and Epigenetics Research Group

RESEARCH GROUP LEADER: Dr. László V. Frenyó, DVM, PhD

CONTACT: frenyo.laszlo@univet.hu

RESEARCH GROUP MEMBERS:

Professors: Dr. László V. Frenyó, Dr. Tibor Bartha

Associate professor: Dr. Ágnes Sterczer

Assistant professor: Dr. Dávid Sándor Kiss

Assistant lecturer: Dr. Istán Tóth

Assistant research fellow: Gergely Jócsák

Assistants: Gréta Goszleth, Zsuzsanna Kinálné Szikora

PhD student: Dr. Zoltán Bárány

 

RESEARCH AREAS:

Focus of research:

immunological features of exotic animals

impact of epigenetic factors on function and development of the immunoendocrine system

epigenetic effects on the up/down-regulation of hormone receptor expression; effects on the immune system

role of microglia in the pathogenesis of hepatic encephalopathy

 

Recent results:

The group is relatively newly reorganized after a few years of silence. Our preliminary results indicate that exogenous disruptor molecules mimicking endogenous hormone effects interact with the immune system.

 

Available equipment:

PCR equipment

Nanodrop for RNA, DNA and protein measurements

ELISA plate reader for quantitative protein/enzyme/hormone/etc. measurements

thermostat and laminar box for investigations on cell cultures

full apparatus for Western blot studies and gel documentation for qualitative and semi-quantitative protein assays

animal house (for rodents and rabbit)

 

MEMBERSHIPS:

Hungarian Physiological Society (MÉT)

Hungarian Society of Animal Protection and Animal Welfare (MÁÁT)

Hungarian Neuroscience Society (MITT)

Research and Technological Innovation

 

LONG-TERM COLLABORATIONS:

University of Iowa, Iowa city, USA

Yale University, Connecticut, USA

University of Veterinary Medicine Hannover, Germany

Hohenheim University, Stuttgart, Germany

Semmelweis University, Hungary

University of Kaposvár, Hungary

Purdue University, Indiana, USA

 

GRANTS:

Funding source

Project title and topic

Amount (HUF)

Research Faculty

(Ministry of Human Capacities)

Establishment of primary astrocyte culture suitable for the investigations of hepatic encephalopathy (2015)

1.500.000

NKB 15991

Co-culture of rat endothelial cells and astrocytes – working out an in vitro model for hepatic encephalopathy

735.000

Research Faculty

(Ministry of Human Capacities)

Examination of the glutaminase inhibiting effects of  a non-specific phosphodiesterase inhibitor, theophyllin on an in vitro model  of hepatic encephalopathy (2016)

1.000.000

Research Faculty

(Ministry of Human Capacities)

Cytokine production in astrocytes as a result of oxidative stress (2016)

1.000.000