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Research Research teams Internal Medicine Research Group

Internal Medicine Research Group

RESEARCH GROUP LEADERS:  Dr. Károly Vörös PhD, DSc, university professor and Dr. Ferenc Manczur PhD., associate professor

CONTACTS: Voros.Karoly@univet.huManczur.Ferenc@univet.hu;

RESEARCH GROUP MEMBERS:

Dr. Ágnes Sterczer

Dr. Márton Balogh

Dr. Csaba Hetyey

Dr. Fruzsina Falus

Dr. Ferenc Manczur

Dr. Gergely Kiss

Dr. Katalin Lányi (Department of Food Hygiene and Safity)

Dr. Noémi Kubik

Dr. Károly Vörös and PhDDr. Zsuzsanna Vizi

Dr. Péter Laczay (Department of Food Hygiene and Safity)

Dr. Zoltán Dudás Györki,

Dr. Zsuzsanna Vizi, Dr. Zsófia Aradi

 

RESEARCH AREAS:

Pathogenesis, diagnosis and treatment of cardiac diseases in dogs and cats; Digital sound recording and processing in cardiologic diagnostics; Clinical diagnostics and therapy of canine heartworm disease.

Pathogenesis, diagnosis and treatment of cardiac diseases in dogs and cats; Digital sound recording and processing in cardiologic diagnostics; Clinical diagnostics and therapy of canine heartworm disease.

Hepcidin (hepatic bactericid protein) is a 25-aminoacid peptide hormon, which is mainly produced in the liver and is the key regulator of the iron homeostasis. Hepcidin binds to the ferroportin causing its internalization and degradation. Through this blocking mechanism, it prevents the iron absorption from the duodenum and iron-outflow from macrophages causing hypoferraemia. Because of the low iron concentration in the blood, there is inefficient amount of iron for the erythropoesis in the bone marrow, causing non-regenerative anemia. The physiological reference values of this recently discovered hormone are not established yet and the clinical significance in the different diseases are not known. The goal of our study is to establish the reference range of the hepcidin in blood and urine in the healthy dogs. The following methods will be used in the research: ELISA and HPLC technics. Our other purpose is to measure the serum concentration of the hepcidin in the different diseases, mainly chronic diseases caused non regenerative anaemia and chronic liver diseases. We assume that the measurement of hepcidin level is an important diagnostic method in dogs as well in the clinical practice.

Pathogenesis, diagnosis and treatment of urological disorders in dogs and cats

Veterinary clinical genetics and genomics- identification of genetic background of inherited diseases in small animals (dogs, cats) by molecular methods

Identification of RNA based cardiac biomarkers in whole blood by molecular methods

Identification of glucocorticoid receptor beta isoform in dogs (in cooperation with Dr. Judit Csöndes and Dr. Péter Vajdovich

 

MEMBERSHIPS:
European Society of Veterinary Cardiology

Gesellschaft für Medizinische Ausbildung

Hungarian Small Animal Veterinary Association

 

Hungarian Society of Ultrasound in Obstetrics and GynecologyEuropean Society of Veterinary Cardiology Gesellschaft für Medizinische Ausbildung

Society of Comparative Hepatology

World Small Animal Veterinary Association

 

LONG-TERM COLLABORATIONS:

AIDR AURICOOP Nonprofit Ltd. (Linda Müller, Péter Trampus, István Novák) /Telemetric blood pressure measurement in dogs/

Dr. Attila Patócs (Semmelweis University,  II. Department of Internal Medicine, Research Laboratory of Endocrine Genetics)

Dr. Ádám Vannay (Semmelweis University, I. Department of Pediatrics, MTA-SE Research Group)

 

Budatétényi Veterinary Clinic Ltd, Dr. László Laczkó, director, veterinarian

Budapest, Prof. Dr. Róbert Farkas, DSc, university professor

Budapest, Dr. Ferenc Szalay, PhD, associate professor

Dr. Balogh Nándor, PhD ECVP Praxislab Kft

Department of Antomy and Histology, University of Veterinary Medicine

Department and Clinic  of Reproduction, University of Veterinary Medicine Budapest (Margit Kulcsár): /RIA examination  of urinary endothelin

Department of Comparative Biomedicine and Food Science BCA. Histological classification of small animal glomerular disorders

Department of Parasitology and Zoology, University of Veterinary Medicine

Luca Aresu, Professor (Associate), University of Padova Italy Padova

 

Praxislab Ltd. (Nándor Balogh) Albumin determination in canine urine by immunoturbidimetric method, SDMA determination from dog and cat samples

Utrecht University, Faculty of Veterinary Medicine,  Department of Clinical Sciences of Companion Animals, the Netherlands, Prof. Dr. Viktor Szatmári, PhD University of Veterinary Medicine Hannover, Klinik für Kleintiere, Germany, Prof. Dr. Ingo Nolte and Dr. Stephan Hungerbühler director of diagnostic ultrasound unit

 

Dr. Violetta Kékesi (The Heart and Vascular Center of Semmelweis University)

WOBE Ltd. (Gabor Bognár) The effect of Dirofilaria repens infection on the kidney function in dogs

 

SERVICES:

complex cardiological examinations (echocardiography, electrocardiography) digital phonocardiographyanalysis of cardiac arrhythmiastesting the effectiveness of drugs used in heart failure and arrhythmia

clinical diagnostics and therapy of canine heartworm disease

complex cardiological examinations (echocardiography, electrocardiography) digital phonocardiographyanalysis of cardiac arrhythmiastesting the effectiveness of drugs used in heart failure and arrhythmia

Hepcidin measurement in  dogs

clinical diagnostics and therapy of canine heartworm disease

complex urological examinations (blood and urinalysis, ultrasound, blood pressure measurements, urine electrophoresis, kidney biopsy)

Small animal clinical genetic counselling, screening tests

 

GRANTS:

Funding source  Project title and topic Amount (HUF)

Research Faculty

(Ministry of Human Capacities)

Farkas, R. and Vörös, K.: New challenges and possibilities in the diagnostics and therapy of  canine heartworm disease.

In the first part of the research, parasitological and molecular biological methods are applied to diagnose the infection of dogs by D. immitis and/or D. repens. Then 7 D. immitis antigen test are used to examine the blood of infected and non-infected dogs. In the second part of the study, infected dogs are sedated with butorphanol before the injection of the adulticide drug melarsomine to decrease local pain and to provide the necessary immobility. The thickness of the lumbar muscles are measured by ultrasonography, then the absorption of melarsomine and the possible local sequela are followed by the method.

 2.000.000

 

Funding source Project title and topic Amount (HUF)
NKB-2016 Search for gene mutations in labradors with isorhythmic atrioventriclar tachycardia  200.000

Research Faculty

(Ministry of Human Capacities)

Detection of the normal hepcidin level with HPLC method in healthy dogs (2013) 1.000.000
Funding source Project title and topic   Amount (HUF)
NKB- 15822 Microalbuminuria in dogs suffering from inflammatory diseases or Dirofilaria infection  200.000
Funding source Project title and topic (date) Amount (HUF)