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Research Research teams Neuroendocrinology Research Group

Neuroendocrinology Research Group

RESEARCH GROUP LEADER: Dr. Tibor Bartha, DVM, PhD

CONTACT: bartha.tibor@univet.hu

RESEARCH GROUP MEMBERS:

Professor: Dr. Tibor Bartha

Associate professor: Dr. Attila Zsarnovszky

Assistant lecturer: Dr.István Tóth

Assistant research fellow: Dr. Ioja Enikő

Postdoctoral research fellow: Dr. Gergely Jócsák

Assistants: Gréta Goszleth, Zsuzsanna Szikora Kinálné, Ildikó Horváth

RESEARCH AREAS:

physiological role of tissue integrity and glial cells in the developing cerebellum

transcriptional and translational changes of different hormone receptors in response to their  different exogenous endocrine disruptors (EDs) in cerebellar cell cultures

effects of EDs on the developing nervous system

role of glial cells in relation to the above aspects

 

Recent results:

We examine the modulating effects of estrogen and thyroid hormones on the expression levels of their receptor (ERs and TRs) mRNAs and proteins in the developing cerebellum on rat as model animal. According to our results, estrogen and thyroid hormone receptor expression depends on the combined presence of estrogen and thyroid hormones; glial cells mediate the hormonal regulation of neuronal ER-TR expression, and loss of tissue integrity results in characteristic changes in ER-TR expression levels. EDs are able to further modulate these complex mechanisms.

 

Available equipment:

  • PCR equipment,
  • Nanodrop for RNA, DNA and protein measurements
  • thermostat and laminar box for cell cultures
  • ELISA plate reader for quantitative protein/enzyme/hormone/etc. measurements
  • complete apparatus for Western blot and gel documentation for qualitative and semi-quantitative protein assays
  • oxygen electrode for mitochondrial measurements, bench top centrifuges
  • equipment for subcellular fractionation
  • animal house (for rodents and rabbit)

MEMBERSHIPS:

Hungarian Physiological Society (MÉT)

Hungarian Society of Animal Protection and Animal Welfare (MÁÁT)

Hungarian Neuroscience Society (MITT)

Research and Technological Innovation Council

LONG-TERM COLLABORATIONS:

University of Leuven, Leuven, Belgium

University of Cincinnati College of Medicine, USA

University of Veterinary Medicine Hannover, Germany

Hohenheim University, Stuttgart, Germany

Eötvös Loránd University, Hungary

University of Kaposvár, Hungary

Purdue University, Indiana, USA

GRANTS:

Funding source

Project title and topic (date)

Amount (HUF)

NKB 15944

Effects of gonadal steroids and satiety on the NTPDase-dependent mitochondrial respiratory rate in the rat hypothalamus

854.000

NKB 15711

 

Analysis of the effects of endocrine disruptors on the expression of estrogen receptors and thyroid hormone receptors in the developing rat cerebellum

325.000

OTKA 104982 National Research, Development and Innovation Office, Hungary (NRDIO)

Analysis of the effects of endocrine disruptors on the expression of estrogen receptors and thyroid hormone receptors in the developing rat cerebellum

29.663.000

NKB JG 15912

 

Analysis of the effects of endocrine distruptors on the expression of estrogen receptors and thyroid hormone receptors in the developing rat cerebellum in vivo

798.000

OTKA 115613 National Research, Development and Innovation Office, Hungary (NRDIO)

Mitochondrial dynamics mediate endocrine disruptors' impact on nuclear receptors

53.785.000