RESEARCH GROUP LEADER: Dr. Tibor Bartha, DVM, PhD
CONTACT: bartha.tibor@univet.hu
RESEARCH GROUP MEMBERS:
Professor: Dr. Tibor Bartha
Associate professor: Dr. Attila Zsarnovszky
Assistant lecturer: Dr.István Tóth
Assistant research fellow: Dr. Ioja Enikő
Postdoctoral research fellow: Dr. Gergely Jócsák
Assistants: Gréta Goszleth, Zsuzsanna Szikora Kinálné, Ildikó Horváth
RESEARCH AREAS:
physiological role of tissue integrity and glial cells in the developing cerebellum
transcriptional and translational changes of different hormone receptors in response to their different exogenous endocrine disruptors (EDs) in cerebellar cell cultures
effects of EDs on the developing nervous system
role of glial cells in relation to the above aspects
Recent results:
We examine the modulating effects of estrogen and thyroid hormones on the expression levels of their receptor (ERs and TRs) mRNAs and proteins in the developing cerebellum on rat as model animal. According to our results, estrogen and thyroid hormone receptor expression depends on the combined presence of estrogen and thyroid hormones; glial cells mediate the hormonal regulation of neuronal ER-TR expression, and loss of tissue integrity results in characteristic changes in ER-TR expression levels. EDs are able to further modulate these complex mechanisms.
Available equipment:
- PCR equipment,
- Nanodrop for RNA, DNA and protein measurements
- thermostat and laminar box for cell cultures
- ELISA plate reader for quantitative protein/enzyme/hormone/etc. measurements
- complete apparatus for Western blot and gel documentation for qualitative and semi-quantitative protein assays
- oxygen electrode for mitochondrial measurements, bench top centrifuges
- equipment for subcellular fractionation
- animal house (for rodents and rabbit)
MEMBERSHIPS:
Hungarian Physiological Society (MÉT)
Hungarian Society of Animal Protection and Animal Welfare (MÁÁT)
Hungarian Neuroscience Society (MITT)
Research and Technological Innovation Council
LONG-TERM COLLABORATIONS:
University of Leuven, Leuven, Belgium
University of Cincinnati College of Medicine, USA
University of Veterinary Medicine Hannover, Germany
Hohenheim University, Stuttgart, Germany
Eötvös Loránd University, Hungary
University of Kaposvár, Hungary
Purdue University, Indiana, USA
GRANTS:
|
Funding source |
Project title and topic (date) |
Amount (HUF) |
|
NKB 15944 |
Effects of gonadal steroids and satiety on the NTPDase-dependent mitochondrial respiratory rate in the rat hypothalamus |
854.000 |
|
NKB 15711
|
Analysis of the effects of endocrine disruptors on the expression of estrogen receptors and thyroid hormone receptors in the developing rat cerebellum |
325.000 |
|
OTKA 104982 National Research, Development and Innovation Office, Hungary (NRDIO) |
Analysis of the effects of endocrine disruptors on the expression of estrogen receptors and thyroid hormone receptors in the developing rat cerebellum |
29.663.000 |
|
NKB JG 15912
|
Analysis of the effects of endocrine distruptors on the expression of estrogen receptors and thyroid hormone receptors in the developing rat cerebellum in vivo |
798.000 |
|
OTKA 115613 National Research, Development and Innovation Office, Hungary (NRDIO) |
Mitochondrial dynamics mediate endocrine disruptors' impact on nuclear receptors |
53.785.000 |
