{"id":4475,"date":"2016-08-02T15:01:00","date_gmt":"2016-08-02T13:01:00","guid":{"rendered":"http:\/\/univet.hu\/about\/staff\/pasztine-dr-gere-erzsebet\/"},"modified":"2026-02-10T04:32:21","modified_gmt":"2026-02-10T03:32:21","slug":"pasztine-dr-gere-erzsebet","status":"publish","type":"page","link":"https:\/\/univet.hu\/en\/about\/staff\/pasztine-dr-gere-erzsebet\/","title":{"rendered":"P\u00e1sztin\u00e9 dr. Gere Erzs\u00e9bet"},"content":{"rendered":"<p><span style=\"font-family: impact, sans-serif;font-size: 14pt\"><strong>Introduction<\/strong><\/span><\/p> <p><strong>Studies<\/strong><\/p> <ul> <li>1995-2000 University of Szeged, Szeged \u2013 Pharmacy (M.Sc.)<\/li> <li>1995-2002 University of Szeged, Szeged \u2013 English (M.Sc.)<\/li> <\/ul> <ul> <li>2009-2012 University of Szeged, Szeged- Pharmacy postgraduate degree<\/li> <li>2010-2013 Szent Istv\u00e1n University, Faculty of Veterinary Science, Budapest \u2013 Veterinary science (Ph.D. )<\/li> <li>2018: Habilitation, University of Veterinary Medicine, Budapest<\/li> <\/ul> <p><strong>Previous positions<\/strong><\/p> <ul> <li>2019- senior research associate, University of Veterinary Medicine, Department of Pharmacology and Toxicology, Budapest<\/li> <li>2014-2019 research associate, University of Veterinary Medicine, Department of Pharmacology and Toxicology, Budapest<\/li> <li>2013-2014 pharmacist, Szent Istv\u00e1n University, Faculty of Veterinary Science, Department of Pharmacology and Toxicology, Budapest<\/li> <li>2010-2013 PhD student, Szent Istv\u00e1n University, Faculty of Veterinary Science, Department of Pharmacology and Toxicology, Budapest<\/li> <\/ul> <p><strong>Teaching <\/strong><\/p> <p><strong>\u00a0<\/strong>Regular lectures and practicals: Pharmacology\/Toxicology in Hungarian and in English (lecturer)<\/p> <ul> <li>Elective lectures: Sportpharmacology, Psychopharmacology and Protein modulators in Hungarian and in English (lecturer and course supervisor)<\/li> <li>Postgraduate courses: Eukaryotic cells, Redox status and oxidative stress in cells (lecturer and course supervisor)<\/li> <li>Supervision of 20 + graduate students (National Scientific Students\u2019 Association) <ul> <li>Barna R\u00e9ka Fanni: National Scientific Students\u2019 Association 2<sup>nd<\/sup> place (Animal physiology)<\/li> <li>Czimmermann Eszter: National Scientific Students\u2019 Association 3<sup>rd<\/sup> place (Animal physiology)<\/li> <li>Szombath Gergely: National Scientific Students\u2019 Association 1<sup>st<\/sup> place (Animal health)<\/li> <\/ul> <\/li> <li>Supervision of PhD student:<\/li> <\/ul> <p>Dr. B\u00fas-Pomothy Judit; title of the PhD thesis: Use of potentially protective substances to maintain the integrity of the intestinal barrier damaged by mycotoxins in in vitro models (2022)<\/p> <p><strong>Further studies<\/strong><\/p> <ul> <li>2002-2003 University of Michigan, Ann Arbor, MI, USA <ul> <li>neuropharmacological research on rat striatal slices<\/li> <\/ul> <\/li> <li>2014 Philipps University, Marburg, Germany <ul> <li>synthesis of matriptase inhibitors, investigation of enzyme kinetics<\/li> <\/ul> <\/li> <\/ul> <p><strong>Membership in Scientific Societies<\/strong><\/p> <p>2011- Hungarian Microbiological Society<\/p> <p><strong>Awards<\/strong><\/p> <ul> <li>2014 Erd\u0151s P\u00e1l Research Fellowship National Excellence Programme<\/li> <li>2015 OTKA postdoctoral fellowship<\/li> <li>2015 Bolyai J\u00e1nos Research Fellowship \u2013 Hungarian Academy of Sciences<\/li> <\/ul> <p><strong>\u00a0<\/strong><\/p> <p><strong>Fundings<\/strong><\/p> <p>2014-2015 KK-UK Study on the effects of matriptase inhibitors on porcine intestinal cells<br \/> 2015-2020 OTKA 115685 Xenobiotics-induced intestinal damage in swine<\/p> <p>2016 KK-KF Preclinical Drug Development Research Group<\/p> <p>2017-2022 OTKA 124522 The effects of probiotics and antioxidants on damage to porcine epithelial cells caused by veterinary pharmaceutical, toxic and infectious agents <em>in vitro<\/em><\/p> <p>&nbsp;<\/p> <p><span style=\"font-family: impact, sans-serif;font-size: 14pt\"><strong>Selected publications (Top10)<\/strong><\/span><\/p> <p style=\"text-align: center\">MTMT: <a href=\"https:\/\/m2.mtmt.hu\/gui2\/?type=authors&amp;mode=browse&amp;sel=authors10023380\">https:\/\/m2.mtmt.hu\/gui2\/?type=authors&amp;mode=browse&amp;sel=authors10023380<\/a><\/p> <hr align=\"center\" size=\"5\" width=\"60%\" \/> <table style=\"height: 279px;width: 113.544%\" width=\"1140\"> <tbody> <tr style=\"height: 86px\"> <td style=\"width: 36px;height: 86px;text-align: center\">1.<\/td> <td style=\"width: 1088px;height: 86px\">Gamba D, van Eijk N, L\u00e1nyi K, Monostory K, Steinmetzer T, Marosi A, R\u00e1cz A, Bajusz D, Kruhl D, B\u00f6ttcher-Friebertsh\u00e4user E, P\u00e1szti-Gere E. PK\/PD investigation of antiviral host matriptase\/TMPRSS2 inhibitors in cell models. Sci Rep. 2024 Jul 18;14(1):16621. doi: 10.1038\/s41598-024-67633-2.<\/td> <\/tr> <tr style=\"height: 54px\"> <td style=\"width: 36px;height: 54px;text-align: center\">2.<\/td> <td style=\"width: 1088px;height: 54px\">Maluck S, Bobrovsky R, Po\u00f3r M, Lange RW, Steinmetzer T, Jerzsele \u00c1, Adorj\u00e1n A, Bajusz D, R\u00e1cz A, P\u00e1szti-Gere E. In Vitro Evaluation of Antipseudomonal Activity and Safety Profile of Peptidomimetic Furin Inhibitors. Biomedicines. 2024 Sep 11;12(9):2075. doi: 10.3390\/biomedicines12092075.<\/td> <\/tr> <tr style=\"height: 54px\"> <td style=\"width: 36px;height: 54px;text-align: center\">3.<\/td> <td style=\"width: 1088px;height: 54px\">van Niekerk AA, Maluck S, Mag P, K\u0151v\u00e1g\u00f3 C, Kerek \u00c1, Jerzsele \u00c1, Steinmetzer T, P\u00e1szti-Gere E. Antiviral Drug Candidate Repositioning for <em>Streptococcus suis<\/em> Infection in Non-Tumorigenic Cell Models. Biomedicines. 2024 Apr 2;12(4):783. doi: 10.3390\/biomedicines12040783.<\/td> <\/tr> <tr style=\"height: 54px\"> <td style=\"width: 36px;height: 54px;text-align: center\">4.<\/td> <td style=\"width: 1088px;height: 54px\">L\u00e1nyi K, Monostory K, Steinmetzer T, Jerzsele \u00c1, P\u00e1szti-Gere E. In Vitro Pharmacokinetic Behavior of Antiviral 3-Amidinophenylalanine Derivatives in Rat, Dog and Monkey Hepatocytes. Biomedicines. 2023 Feb 23;11(3):682. doi: 10.3390\/biomedicines11030682.<\/td> <\/tr> <tr style=\"height: 31px\"> <td style=\"width: 36px;height: 31px;text-align: center\">5.<\/td> <td style=\"width: 1088px;height: 31px\">van Eijk N, Schmacke LC, Steinmetzer T, Pilgram O, Po\u00f3r M, P\u00e1szti-Gere E. In vitro testing of host-targeting small molecule antiviral matriptase\/TMPRSS2 inhibitors in 2D and 3D cell-based assays. Biomed Pharmacother. 2023 Dec;168:115761. doi: 10.1016\/j.biopha.2023.115761. Epub 2023 Oct 20.<\/td> <\/tr> <tr> <td style=\"width: 36px;text-align: center\">6.<\/td> <td style=\"width: 1088px\">Fedor Z, Szentkir\u00e1lyi-T\u00f3th A, Nagy G, Szimr\u00f3k Z, Varga E, P\u00e1szti A, P\u00e1szti Z, Jerzsele \u00c1, Pilgram O, Steinmetzer T, M\u00e1tis G, Neogr\u00e1dy Z, P\u00e1szti-Gere E. Interspecies Comparisons of the Effects of Potential Antiviral 3-Amidinophenylalanine Derivatives on Cytochrome P450 1A2 Isoenzyme. Vet Sci. 2022 Mar 23;9(4):156. doi: 10.3390\/vetsci9040156.<\/td> <\/tr> <tr> <td style=\"width: 36px;text-align: center\">7.<\/td> <td style=\"width: 1088px\">P\u00e1szti-Gere E, Szentkir\u00e1lyi-T\u00f3th A, Szab\u00f3 P, Steinmetzer T, Flisz\u00e1r-Ny\u00fal E, Po\u00f3r M. In vitro characterization of the furin inhibitor MI-1851: Albumin binding, interaction with cytochrome P450 enzymes and cytotoxicity. Biomed Pharmacother. 2022 Jul;151:113124. doi: 10.1016\/j.biopha.2022.113124. Epub 2022 May 17.<\/td> <\/tr> <tr> <td style=\"width: 36px;text-align: center\">8.<\/td> <td style=\"width: 1088px\">P\u00e1szti-Gere E, Szentkir\u00e1lyi A, Fedor Z, Nagy G, Szimr\u00f3k Z, P\u00e1szti Z, P\u00e1szti A, Pilgram O, Steinmetzer T, Bodn\u00e1rov\u00e1 S, Flisz\u00e1r-Ny\u00fal E, Po\u00f3r M. In vitro interaction of potential antiviral TMPRSS2 inhibitors with human serum albumin and cytochrome P 450 isoenzymes. Biomed Pharmacother. 2022 Feb;146:112513. doi: 10.1016\/j.biopha.2021.112513. Epub 2021 Dec 13.<\/td> <\/tr> <tr> <td style=\"width: 36px;text-align: center\">9.<\/td> <td style=\"width: 1088px\">Wohlert A, Palkovicsn\u00e9 P\u00e9zsa N, M\u00f3ritz AV, Jerzsele \u00c1, Farkas O, P\u00e1szti-Gere E. Luteolin and Chrysin Could Prevent <em>E. coli<\/em> Lipopolysaccharide-Ochratoxin A Combination-Caused Inflammation and Oxidative Stress in In Vitro Porcine Intestinal Model. Animals (Basel). 2022 Oct 13;12(20):2747. doi: 10.3390\/ani12202747.<\/td> <\/tr> <tr> <td style=\"width: 36px;text-align: center\">10.<\/td> <td style=\"width: 1088px\">P\u00e1szti-Gere E, Pomothy J, Jerzsele \u00c1, Pilgram O, Steinmetzer T. Exposure of human intestinal epithelial cells and primary human hepatocytes to trypsin-like serine protease inhibitors with potential antiviral effect. J Enzyme Inhib Med Chem. 2021 Dec;36(1):659-668. doi: 10.1080\/14756366.2021.1886093.<\/td> <\/tr> <\/tbody> <\/table> <p>&nbsp;<\/p> <p style=\"text-align: center\">(Updated: January 2025)<\/p>","protected":false},"excerpt":{"rendered":"<p>Introduction Studies 1995-2000 University of Szeged, Szeged \u2013 Pharmacy (M.Sc.) 1995-2002 University of Szeged, Szeged \u2013 English (M.Sc.) 2009-2012 University of Szeged, Szeged- Pharmacy postgraduate degree 2010-2013 Szent Istv\u00e1n University, Faculty of Veterinary Science, Budapest \u2013 Veterinary science (Ph.D. ) 2018: Habilitation, University of Veterinary Medicine, Budapest Previous positions 2019- senior research associate, University of<\/p>\n","protected":false},"author":5824,"featured_media":0,"parent":857,"menu_order":211,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"categories":[19],"tags":[],"class_list":["post-4475","page","type-page","status-publish","hentry","category-staff"],"acf":[],"_links":{"self":[{"href":"https:\/\/univet.hu\/en\/wp-json\/wp\/v2\/pages\/4475","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/univet.hu\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/univet.hu\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/univet.hu\/en\/wp-json\/wp\/v2\/users\/5824"}],"replies":[{"embeddable":true,"href":"https:\/\/univet.hu\/en\/wp-json\/wp\/v2\/comments?post=4475"}],"version-history":[{"count":2,"href":"https:\/\/univet.hu\/en\/wp-json\/wp\/v2\/pages\/4475\/revisions"}],"predecessor-version":[{"id":172931,"href":"https:\/\/univet.hu\/en\/wp-json\/wp\/v2\/pages\/4475\/revisions\/172931"}],"up":[{"embeddable":true,"href":"https:\/\/univet.hu\/en\/wp-json\/wp\/v2\/pages\/857"}],"wp:attachment":[{"href":"https:\/\/univet.hu\/en\/wp-json\/wp\/v2\/media?parent=4475"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/univet.hu\/en\/wp-json\/wp\/v2\/categories?post=4475"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/univet.hu\/en\/wp-json\/wp\/v2\/tags?post=4475"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}