{"id":79857,"date":"2022-10-26T14:32:30","date_gmt":"2022-10-26T12:32:30","guid":{"rendered":"https:\/\/univet.hu\/en\/research\/research-teams\/redox-biology-laboratory\/name\/"},"modified":"2022-10-26T15:09:56","modified_gmt":"2022-10-26T13:09:56","slug":"research-overview","status":"publish","type":"page","link":"https:\/\/univet.hu\/en\/research\/research-teams\/redox-biology-research-group\/research-overview\/","title":{"rendered":"Overview"},"content":{"rendered":"<p><strong><u>Overview<\/u><\/strong><\/p> <p>All cells require disulfide reducing power to support homeostasis.<\/p> <p>Disulfide reducing power:<\/p> <p><em><u>The ability to reduce disulfide bonds into di-thiols and then to use re-oxidation of di-thiols into disulfides to drive reduction of other substrates<\/u><\/em><\/p> <p>At its most basal level, this process allows cells to produce DNA precursors for DNA repair and replication: a fundamental requirement of all cells of all forms of life on earth.<\/p> <p>In aerobic organisms, disulfide reducing power also fuels antioxidant systems.<\/p> <p>Antioxidant systems:<\/p> <p><em><u>Detoxify potentially harmful oxidants, such as H<sub>2<\/sub>O<sub>2<\/sub> or free radicals<\/u><\/em>.<\/p> <p>Further, particularly in complex metazoan animals, disulfide reducing power underpins mechanisms of redox signaling that regulate many cellular and organismal processes. Research at the <strong><u>Redox Biology Laboratory (RBL)<\/u><\/strong> at the University of Veterinary Medicine studies these processes, from the basal biology and physiology of redox systems to antioxidant stress responses to redox signaling to redox-associated diseases, including cancer and inflammation. The RBL opened in 2021 and currently has two actively funded projects.<\/p> <p>&nbsp;<\/p>","protected":false},"excerpt":{"rendered":"<p>Overview All cells require disulfide reducing power to support homeostasis. Disulfide reducing power: The ability to reduce disulfide bonds into di-thiols and then to use re-oxidation of di-thiols into disulfides to drive reduction of other substrates At its most basal level, this process allows cells to produce DNA precursors for DNA repair and replication: a<\/p>\n","protected":false},"author":4210,"featured_media":0,"parent":70065,"menu_order":0,"comment_status":"open","ping_status":"open","template":"","meta":{"_acf_changed":false,"footnotes":""},"categories":[],"tags":[],"class_list":["post-79857","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/univet.hu\/en\/wp-json\/wp\/v2\/pages\/79857","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/univet.hu\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/univet.hu\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/univet.hu\/en\/wp-json\/wp\/v2\/users\/4210"}],"replies":[{"embeddable":true,"href":"https:\/\/univet.hu\/en\/wp-json\/wp\/v2\/comments?post=79857"}],"version-history":[{"count":0,"href":"https:\/\/univet.hu\/en\/wp-json\/wp\/v2\/pages\/79857\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/univet.hu\/en\/wp-json\/wp\/v2\/pages\/70065"}],"wp:attachment":[{"href":"https:\/\/univet.hu\/en\/wp-json\/wp\/v2\/media?parent=79857"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/univet.hu\/en\/wp-json\/wp\/v2\/categories?post=79857"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/univet.hu\/en\/wp-json\/wp\/v2\/tags?post=79857"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}