{"id":891,"date":"2017-06-27T10:43:00","date_gmt":"2017-06-27T08:43:00","guid":{"rendered":"http:\/\/univet.hu\/about-us\/research\/research-teams\/metabolic-biochemistry-research-group\/"},"modified":"2026-05-20T14:26:26","modified_gmt":"2026-05-20T12:26:26","slug":"metabolic-biochemistry-research-group","status":"publish","type":"page","link":"https:\/\/univet.hu\/en\/research\/research-teams\/metabolic-biochemistry-research-group\/","title":{"rendered":"Metabolic Biochemistry Research Group"},"content":{"rendered":"
RESEARCH GROUP NAME<\/strong><\/td> Metabolic Biochemistry Research Group<\/td> <\/tr>
Head of the research group<\/strong><\/td> <\/td> <\/tr>
Name<\/td> Dr. M\u00e1t\u00e9 Mackei<\/td> <\/tr>
Academic degree<\/td> Assistant professor<\/td> <\/tr>
Organizational unit<\/td> Department of Physiology and Biochemistry<\/td> <\/tr>
Email address<\/td> [Click to see email]<\/a><\/td> <\/tr>
Members of the research group<\/strong><\/td> Dr. S\u00e1ra Fanni Huber<\/td> <\/tr>
Dr. Evelin K\u00e1m\u00e1n-T\u00f3th, PhD<\/td> <\/tr>
Dr. Zsuzsanna Neogr\u00e1dy, CSc<\/td> <\/tr>
J\u00falia V\u00f6r\u00f6sh\u00e1zi<\/td> <\/tr>
Dr. G\u00e1bor M\u00e1tis, PhD<\/td> <\/tr>
Brief description of research topics<\/strong><\/td> The primary aim of the research group is to explore the cellular and organism-level effects of various environmentally derived harmful factors\u2014such as mycotoxins, pesticides, and heat stress\u2014and to investigate their impact on molecular and metabolic processes. To achieve this, advanced in vitro models, including liver cell-based 3D spheroids, are utilized. In addition, the study of honey bees also plays a significant role within the group. Special emphasis is placed on the analysis of oxidative stress, inflammatory processes, and changes in immune responses, as well as on uncovering the compensatory and defensive mechanisms of cells and organisms. In the course of the group\u2019s work, modern multiplex Luminex-based technology is also employed for high-throughput protein and cytokine profiling. The research further includes the investigation of the potential applications of protective bioactive substances that may contribute to enhancing the resilience of the studied cell cultures and honey bee models. Furthermore, innovative RNA interference (RNAi) technology is applied in honey bees for targeted regulation of immune processes and for combating infectious diseases, such as Varroa mite or Nosema infection. In addition to monitoring changes in redox homeostasis and fatty acid profiles, the examination of parameters such as mRNS and protein levels, as well as certain heat shock proteins (HSP), plays a key role in bee health testing.<\/td> <\/tr>
Five outstanding international publications by the research group published in the past 5 years<\/strong><\/td> <\/td> <\/tr>
<\/td> 1. Mackei, M., Seb\u0151k, C., V\u00f6r\u00f6h\u00e1zi, J., Tr\u00e1j, P., Mackei, F., Ol\u00e1h, B., … & M\u00e1tis, G. (2023). Detrimental consequences of tebuconazole on redox homeostasis and fatty acid profile of honeybee brain. Insect Biochemistry and Molecular Biology, 159, 103990.<\/td> <\/tr>
2. V\u00f6r\u00f6sh\u00e1zi, J., Mackei, M., Seb\u0151k, C., Tr\u00e1j, P., M\u00e1rton, R. A., Horv\u00e1th, D. G., … & M\u00e1tis, G. (2024). Investigation of the effects of T-2 toxin in chicken-derived three-dimensional hepatic cell cultures. Scientific Reports, 14(1), 1195.<\/td> <\/tr>
3. Mackei, M., Huber, F., Seb\u0151k, C., V\u00f6r\u00f6sh\u00e1zi, J., Tr\u00e1j, P., M\u00e1rton, R. A., … & M\u00e1tis, G. (2024). Unraveling the acute sublethal effects of acetamiprid on honey bee neurological redox equilibrium. Scientific Reports, 14(1), 27514.<\/td> <\/tr>
4. V\u00f6r\u00f6sh\u00e1zi, J., Neogr\u00e1dy, Z., M\u00e1tis, G., & Mackei, M. (2024). Pathological consequences, metabolism and toxic effects of trichothecene T-2 toxin in poultry. Poultry Science, 103471.<\/td> <\/tr>
5.Mackei, M., Huber, F., Seb\u0151k, C., V\u00f6r\u00f6sh\u00e1zi, J., Tr\u00e1j, P., M\u00e1rton, R. A., … & M\u00e1tis, G. (2025). Effective adaptation of flight muscles to tebuconazole-induced oxidative stress in honey bees. Heliyon, 11(1).<\/td> <\/tr>
Domestic and international grants awarded to the research group that are active or not older than 5 years<\/strong><\/td> OTKA FK Grant \u2013 Awarded \u2013 OTKA FK No. 146534; Investigation of detrimental environmental factors and protective bioactive substances in honeybees. 42,000,000 Ft<\/td> <\/tr>
EK\u00d6P Young Researcher Scholarship \u2013 M\u00e1t\u00e9 Mackei \u2013 Investigation of the effects of heat stress and the potential applications of protective substances in hepatic cell cultures. 480,000 Ft<\/td> <\/tr>
Young researcher grant of the University of Veterinary medicine Budapest (2023),3,900,000 Ft<\/td> <\/tr>
International relations and collaborations<\/strong><\/td> Collaboration with several research groups within certain COLOSS honey bee health working groups. World Honey Bee Health Task Force \u2013 Prof. Jamie Ellis, University of Florida (US); Climate Change Task Force \u2013 Prof. Peter Neumann, University of Bern (CH); Dr. Kirsten Traynor, University of Hohenheim (DE). Collaboration with Prof. Korinna Huber (University of Hohenheim, Germany) in the field of in vitro metabolomics studies.<\/td> <\/tr>
Industrial relations and collaborations<\/strong><\/td> <\/td> <\/tr> <\/tbody> <\/table>

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RESEARCH GROUP NAME Metabolic Biochemistry Research Group Head of the research group Name Dr. M\u00e1t\u00e9 Mackei Academic degree Assistant professor Organizational unit Department of Physiology and Biochemistry Email address [Click to see email] Members of the research group Dr. S\u00e1ra Fanni Huber Dr. Evelin K\u00e1m\u00e1n-T\u00f3th, PhD Dr. Zsuzsanna Neogr\u00e1dy, CSc J\u00falia V\u00f6r\u00f6sh\u00e1zi Dr. G\u00e1bor M\u00e1tis,<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":869,"menu_order":228,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"categories":[],"tags":[],"class_list":["post-891","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/univet.hu\/en\/wp-json\/wp\/v2\/pages\/891","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/univet.hu\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/univet.hu\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/univet.hu\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/univet.hu\/en\/wp-json\/wp\/v2\/comments?post=891"}],"version-history":[{"count":2,"href":"https:\/\/univet.hu\/en\/wp-json\/wp\/v2\/pages\/891\/revisions"}],"predecessor-version":[{"id":207541,"href":"https:\/\/univet.hu\/en\/wp-json\/wp\/v2\/pages\/891\/revisions\/207541"}],"up":[{"embeddable":true,"href":"https:\/\/univet.hu\/en\/wp-json\/wp\/v2\/pages\/869"}],"wp:attachment":[{"href":"https:\/\/univet.hu\/en\/wp-json\/wp\/v2\/media?parent=891"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/univet.hu\/en\/wp-json\/wp\/v2\/categories?post=891"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/univet.hu\/en\/wp-json\/wp\/v2\/tags?post=891"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}