{"id":34012,"date":"2025-02-13T12:44:32","date_gmt":"2025-02-13T11:44:32","guid":{"rendered":"https:\/\/univet.hu\/?page_id=34012"},"modified":"2025-02-13T12:44:32","modified_gmt":"2025-02-13T11:44:32","slug":"124-triazol-5-onok-szintezise-nitroenaminokbol-amidrazonokon-keresztul","status":"publish","type":"page","link":"https:\/\/univet.hu\/hu\/egyetem\/szervezeti-egysegek\/kemiai-tanszek\/kutatas\/124-triazol-5-onok-szintezise-nitroenaminokbol-amidrazonokon-keresztul\/","title":{"rendered":"1,2,4-triazol-5-onok szint\u00e9zise nitroenaminokb\u00f3l amidrazonokon kereszt\u00fcl"},"content":{"rendered":"<p><strong>Kutat\u00e1si terv: <\/strong><\/p> <p>Irodalmi \u00e1ttekint\u00e9s:<\/p> <p>T\u00f6bb, mint sz\u00e1z \u00e9ve ismert az 1,2,4-triazol alapmolekula. Sz\u00e1rmaz\u00e9kainak szint\u00e9zis\u00e9r\u0151l \u00e9s azok farmakol\u00f3giai vizsg\u00e1lat\u00e1r\u00f3l sz\u00f3l\u00f3 cikkek \u00e9s szabadalmak mindazon\u00e1ltal exponenci\u00e1lisan n\u00f6vekednek (1. \u00e1bra). Az ok a rendk\u00edv\u00fcl szerte\u00e1gaz\u00f3 biol\u00f3giai hat\u00e1sban keresend\u0151: antibakteri\u00e1lis, antivir\u00e1lis, gombaellenes, tumorg\u00e1tl\u00f3, gyullad\u00e1scs\u00f6kkent\u0151, g\u00f6rcsold\u00f3, antioxid\u00e1ns \u00e9s herbicid vegy\u00fcleteket tal\u00e1lhatunk sz\u00e9p sz\u00e1mmal k\u00f6z\u00f6tt\u00fck<sup>1-5<\/sup>.<\/p> <p>&nbsp;<\/p> <p style=\"text-align: center;\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone  wp-image-34016\" src=\"https:\/\/univet.hu\/wp-content\/uploads\/2019\/02\/VTR_1-295x320.png\" data-replaced=\"true\" alt=\"\" width=\"389\" height=\"422\" srcset=\"https:\/\/univet.hu\/wp-content\/uploads\/2019\/02\/VTR_1-295x320.png 295w, https:\/\/univet.hu\/wp-content\/uploads\/2019\/02\/VTR_1-768x833.png 768w, https:\/\/univet.hu\/wp-content\/uploads\/2019\/02\/VTR_1.png 840w\" sizes=\"auto, (max-width: 389px) 100vw, 389px\" \/><\/p> <p style=\"text-align: center;\">1. \u00e1bra<\/p> <p>Eddigi saj\u00e1t eredm\u00e9nyek:<\/p> <p>Nitro-enaminokb\u00f3l diazot\u00e1l\u00e1ssal nitrazonokat szintetiz\u00e1ltunk, amelyekb\u0151l amidrazonokat \u00e1ll\u00edtottunk el\u0151. A szint\u00e9zist optimaliz\u00e1ltuk: old\u00f3szer, kataliz\u00e1tor, h\u0151m\u00e9rs\u00e9klet, reakci\u00f3id\u0151. Err\u0151l egy hazai konferenci\u00e1n sz\u00e1moltunk be<sup>6<\/sup> (2. \u00e1bra), valamint egy B.Sc. szakdolgozat is elk\u00e9sz\u00fclt bel\u0151le (Nagy D\u00e1niel). Eddig kilenc \u00faj triazolont \u00e1ll\u00edtottunk el\u0151 \u00e9s karakteriz\u00e1ltuk NMR ill. HRMS m\u00f3dszerekkel.<\/p> <p>&nbsp;<\/p> <p style=\"text-align: center;\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-34017\" src=\"https:\/\/univet.hu\/wp-content\/uploads\/2019\/02\/VTR_2-320x110.png\" data-replaced=\"true\" alt=\"\" width=\"489\" height=\"168\" srcset=\"https:\/\/univet.hu\/wp-content\/uploads\/2019\/02\/VTR_2-320x110.png 320w, https:\/\/univet.hu\/wp-content\/uploads\/2019\/02\/VTR_2.png 458w\" sizes=\"auto, (max-width: 489px) 100vw, 489px\" \/><\/p> <p style=\"text-align: center;\">2. \u00e1bra<\/p> <p>&nbsp;<\/p> <p>A javasolt kutat\u00e1si t\u00e9ma fontoss\u00e1g\u00e1nak az indokl\u00e1sa:<\/p> <p>\u00daj, potenci\u00e1lisan farmakol\u00f3giailag akt\u00edv molekul\u00e1k szint\u00e9zise (l\u00e1sd irodalmi \u00e1ttekint\u00e9s). A nitrazon \u00ae amidrazon \u00e1talakul\u00e1st \u00faj, az irodalomban eddig nem publik\u00e1lt m\u00f3dszerrel val\u00f3s\u00edtottuk meg.<\/p> <p>&nbsp;<\/p> <p>V\u00e1zlatos kutat\u00e1si terv:<\/p> <p>Az el\u0151\u00e1ll\u00edtott amidrazonok reakt\u00edv C<sub>1<\/sub>-szintonokkal (<em>pl.<\/em> karbonildiimidazol) 1,2,4-triazol gy\u0171r\u0171v\u00e9 z\u00e1rhat\u00f3k. A c\u00e9lmolekula az R<sup>1<\/sup> \u00e9s R<sup>2<\/sup> csoportokon, valamint a 1,2,4-triazol gy\u0171r\u0171 3-as sz\u00e9natomj\u00e1n l\u00e9v\u0151 heterociklus gy\u0171r\u0171tagsz\u00e1m\u00e1nak n\u00f6vel\u00e9s\u00e9vel (6, 7) diverzifik\u00e1lhat\u00f3 (3. \u00e1bra).<\/p> <p>&nbsp;<\/p> <p style=\"text-align: center;\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-34018\" src=\"https:\/\/univet.hu\/wp-content\/uploads\/2019\/02\/VTR_3.png\" data-replaced=\"true\" alt=\"\" width=\"258\" height=\"168\" \/><\/p> <p style=\"text-align: center;\">3. \u00e1bra<\/p> <p>V\u00e1rhat\u00f3 eredm\u00e9nyek:<\/p> <p>Lehet\u0151s\u00e9g van tov\u00e1bbi \u00faj amidrazon ill. 1,2,4-triazol-sz\u00e1rmaz\u00e9k szint\u00e9zis\u00e9re. A term\u00e9kek farmakol\u00f3giai vizsg\u00e1lat\u00e1t k\u00fcls\u0151 partner v\u00e9gzi el.<\/p> <p>&nbsp;<\/p> <p>(1) A. Moulin et al: Synthesis of 3,4,5-Trisubstituted-1,2,4-triazoles, <em>Chemical Reviews <\/em><strong><em>2010, <\/em><\/strong><em>110, <\/em><em>1809\u20131827<\/em><\/p> <p>(2) J. K. Shneine and Y. H. Alaraji: Chemistry of 1, 2, 4-Triazole: A Review Article, <em>International Journal of Science and Research, <strong>2016<\/strong>, 5, 1411-1423<\/em><\/p> <p>(3) S. Pratap et al: Therapeutic quest of 1, 2, 4- triazole and its derivatives: A review, <em>International Journal of Pharmaceutical Science and Research, <strong>2017<\/strong>, 2, 52-56<\/em><\/p> <p>(4) D. Gupta and D. K. Jain: Synthesis, antifungal and antibacterial activity of novel 1,2,4\u2011triazole derivatives, <em>Journal of Advanced Pharmaceutical Technology &amp; Research, <strong>2015<\/strong>, 6, 141-146<\/em><\/p> <p>(5) S. Maddila et al: 1,2,4-Triazoles: A Review of Synthetic Approaches and the Biological Activity, <em>Letters in Organic Chemistry, <\/em><strong><em>2013<\/em><\/strong><em>, 10, 693-714<\/em><\/p> <p>(6) Pilipecz M., Varga T. \u00e9s Alekszi-Kasz\u00e1s A.: Azaborolok szint\u00e9zise b-nitroenaminokb\u00f3l, <em>MTA Heterociklusos K\u00e9miai Munkabizotts\u00e1g \u00dcl\u00e9s<\/em>, <em>Balatonszemes, 2017. m\u00e1jus 15-17.<\/em><\/p> <p>&nbsp;<\/p> <p>D\u00e1tum: Budapest, 2019. \u00e9v febru\u00e1r 12.<\/p>","protected":false},"excerpt":{"rendered":"<p>Kutat\u00e1si terv: Irodalmi \u00e1ttekint\u00e9s: T\u00f6bb, mint sz\u00e1z \u00e9ve ismert az 1,2,4-triazol alapmolekula. Sz\u00e1rmaz\u00e9kainak szint\u00e9zis\u00e9r\u0151l \u00e9s azok farmakol\u00f3giai vizsg\u00e1lat\u00e1r\u00f3l sz\u00f3l\u00f3 cikkek \u00e9s szabadalmak mindazon\u00e1ltal exponenci\u00e1lisan n\u00f6vekednek (1. \u00e1bra). Az ok a rendk\u00edv\u00fcl szerte\u00e1gaz\u00f3 biol\u00f3giai hat\u00e1sban keresend\u0151: antibakteri\u00e1lis, antivir\u00e1lis, gombaellenes, tumorg\u00e1tl\u00f3, gyullad\u00e1scs\u00f6kkent\u0151, g\u00f6rcsold\u00f3, antioxid\u00e1ns \u00e9s herbicid vegy\u00fcleteket tal\u00e1lhatunk sz\u00e9p sz\u00e1mmal k\u00f6z\u00f6tt\u00fck1-5. &nbsp; 1. \u00e1bra Eddigi saj\u00e1t eredm\u00e9nyek:<\/p>\n","protected":false},"author":3837,"featured_media":0,"parent":13635,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"categories":[],"tags":[],"class_list":["post-34012","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/univet.hu\/hu\/wp-json\/wp\/v2\/pages\/34012","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/univet.hu\/hu\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/univet.hu\/hu\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/univet.hu\/hu\/wp-json\/wp\/v2\/users\/3837"}],"replies":[{"embeddable":true,"href":"https:\/\/univet.hu\/hu\/wp-json\/wp\/v2\/comments?post=34012"}],"version-history":[{"count":1,"href":"https:\/\/univet.hu\/hu\/wp-json\/wp\/v2\/pages\/34012\/revisions"}],"predecessor-version":[{"id":175613,"href":"https:\/\/univet.hu\/hu\/wp-json\/wp\/v2\/pages\/34012\/revisions\/175613"}],"up":[{"embeddable":true,"href":"https:\/\/univet.hu\/hu\/wp-json\/wp\/v2\/pages\/13635"}],"wp:attachment":[{"href":"https:\/\/univet.hu\/hu\/wp-json\/wp\/v2\/media?parent=34012"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/univet.hu\/hu\/wp-json\/wp\/v2\/categories?post=34012"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/univet.hu\/hu\/wp-json\/wp\/v2\/tags?post=34012"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}