{"id":11046,"date":"2016-02-04T16:00:00","date_gmt":"2016-02-04T15:00:00","guid":{"rendered":"https:\/\/univet.hu\/kat\/topics\/cytochrome-system-in-livestock-the-effect-of-feed-additives-on-cyp-enzymes-in-drug-metabolism\/"},"modified":"2016-02-04T16:00:00","modified_gmt":"2016-02-04T15:00:00","slug":"cytochrome-system-in-livestock-the-effect-of-feed-additives-on-cyp-enzymes-in-drug-metabolism","status":"publish","type":"page","link":"https:\/\/univet.hu\/kat\/en\/topics\/cytochrome-system-in-livestock-the-effect-of-feed-additives-on-cyp-enzymes-in-drug-metabolism\/","title":{"rendered":"Cytochrome system in livestock, the effect of feed additives on CYP enzymes in drug metabolism"},"content":{"rendered":"<p>Gy\u00f6rgy Csik\u00f3, Orsolya Pal\u00f3cz<\/p> <p class=\"sorbe\">The cytochrome P450 (CYP450) enzymes catalyze the metabolism of numerous endogenous and exogenous compounds. The enzymes of the CYP1, CYP2 and CYP3 families primarily take part in the transformation of drugs and other xenobiotics. Any alterations occurring in the activity of the CYP450 enzymes have an effect on the formation of the drug metabolites in the body. These hem containing, endoplasmic reticulum bound enzymes can be found in basically any organism although their quantity and activity is species specific, the liver contains CYP enzymes in the highest amount.<\/p> <p class=\"sorbe\">We determine the effect of beneficial feed additives on CYP450 enzyme system, CYP enzyme activity, CYP gene expression will be measured by luminescence and qRT-PCR methods, respectively in rabbits, chickens and pigs both in vivo and in vitro.<\/p>","protected":false},"excerpt":{"rendered":"<p>Gy\u00f6rgy Csik\u00f3, Orsolya Pal\u00f3cz The cytochrome P450 (CYP450) enzymes catalyze the metabolism of numerous endogenous and exogenous compounds. The enzymes of the CYP1, CYP2 and CYP3 families primarily take part in the transformation of drugs and other xenobiotics. Any alterations occurring in the activity of the CYP450 enzymes have an effect on the formation of<\/p>\n","protected":false},"author":0,"featured_media":0,"parent":873,"menu_order":154,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"categories":[],"tags":[],"class_list":["post-11046","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Cytochrome system in livestock, the effect of feed additives on CYP enzymes in drug metabolism - University of Veterinary Medicine Budapest<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/univet.hu\/kat\/en\/topics\/cytochrome-system-in-livestock-the-effect-of-feed-additives-on-cyp-enzymes-in-drug-metabolism\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Cytochrome system in livestock, the effect of feed additives on CYP enzymes in drug metabolism - University of Veterinary Medicine Budapest\" \/>\n<meta property=\"og:description\" content=\"Gy\u00f6rgy Csik\u00f3, Orsolya Pal\u00f3cz The cytochrome P450 (CYP450) enzymes catalyze the metabolism of numerous endogenous and exogenous compounds. The enzymes of the CYP1, CYP2 and CYP3 families primarily take part in the transformation of drugs and other xenobiotics. Any alterations occurring in the activity of the CYP450 enzymes have an effect on the formation of\" \/>\n<meta property=\"og:url\" content=\"https:\/\/univet.hu\/kat\/en\/topics\/cytochrome-system-in-livestock-the-effect-of-feed-additives-on-cyp-enzymes-in-drug-metabolism\/\" \/>\n<meta property=\"og:site_name\" content=\"University of Veterinary Medicine Budapest\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/univet.hu\/kat\/en\/topics\/cytochrome-system-in-livestock-the-effect-of-feed-additives-on-cyp-enzymes-in-drug-metabolism\/\",\"url\":\"https:\/\/univet.hu\/kat\/en\/topics\/cytochrome-system-in-livestock-the-effect-of-feed-additives-on-cyp-enzymes-in-drug-metabolism\/\",\"name\":\"Cytochrome system in livestock, the effect of feed additives on CYP enzymes in drug metabolism - University of Veterinary Medicine Budapest\",\"isPartOf\":{\"@id\":\"https:\/\/univet.hu\/kat\/#website\"},\"datePublished\":\"2016-02-04T15:00:00+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/univet.hu\/kat\/en\/topics\/cytochrome-system-in-livestock-the-effect-of-feed-additives-on-cyp-enzymes-in-drug-metabolism\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/univet.hu\/kat\/en\/topics\/cytochrome-system-in-livestock-the-effect-of-feed-additives-on-cyp-enzymes-in-drug-metabolism\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/univet.hu\/kat\/en\/topics\/cytochrome-system-in-livestock-the-effect-of-feed-additives-on-cyp-enzymes-in-drug-metabolism\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Kezd\u0151lap\",\"item\":\"https:\/\/univet.hu\/kat\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Topics\",\"item\":\"https:\/\/univet.hu\/kat\/en\/topics\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Cytochrome system in livestock, the effect of feed additives on CYP enzymes in drug metabolism\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/univet.hu\/kat\/#website\",\"url\":\"https:\/\/univet.hu\/kat\/\",\"name\":\"Univet Katal\u00f3gus\",\"description\":\"Since 1787\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/univet.hu\/kat\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Cytochrome system in livestock, the effect of feed additives on CYP enzymes in drug metabolism - University of Veterinary Medicine Budapest","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/univet.hu\/kat\/en\/topics\/cytochrome-system-in-livestock-the-effect-of-feed-additives-on-cyp-enzymes-in-drug-metabolism\/","og_locale":"en_US","og_type":"article","og_title":"Cytochrome system in livestock, the effect of feed additives on CYP enzymes in drug metabolism - University of Veterinary Medicine Budapest","og_description":"Gy\u00f6rgy Csik\u00f3, Orsolya Pal\u00f3cz The cytochrome P450 (CYP450) enzymes catalyze the metabolism of numerous endogenous and exogenous compounds. 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