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About Us Staff Pásztiné dr. Gere Erzsébet

dr. Pásztiné dr. Gere Erzsébet

PhD.
Department
Department of Pharmacology and Toxicology
Position
associate researcher
Location
Building S 1st floor
Email
[Click to see email]
Phone
(1) 478 4100/8567

Introduction

Studies

  • 1995-2000 University of Szeged, Szeged – Pharmacy (M.Sc.)
  • 1995-2002 University of Szeged, Szeged – English (M.Sc.)
  • 2009-2012 University of Szeged, Szeged- Pharmacy postgraduate degree
  • 2010-2013 Szent István University, Faculty of Veterinary Science, Budapest – Veterinary science (Ph.D. )
  • 2018: Habilitation, University of Veterinary Medicine, Budapest

Previous positions

  • 2019- senior research associate, University of Veterinary Medicine, Department of Pharmacology and Toxicology, Budapest
  • 2014-2019 research associate, University of Veterinary Medicine, Department of Pharmacology and Toxicology, Budapest
  • 2013-2014 pharmacist, Szent István University, Faculty of Veterinary Science, Department of Pharmacology and Toxicology, Budapest
  • 2010-2013 PhD student, Szent István University, Faculty of Veterinary Science, Department of Pharmacology and Toxicology, Budapest

Teaching

 Regular lectures and practicals: Pharmacology/Toxicology in Hungarian and in English (lecturer)

  • Elective lectures: Sportpharmacology, Psychopharmacology and Protein modulators in Hungarian and in English (lecturer and course supervisor)
  • Postgraduate courses: Eukaryotic cells, Redox status and oxidative stress in cells (lecturer and course supervisor)
  • Supervision of 20 + graduate students (National Scientific Students’ Association)
    • Barna Réka Fanni: National Scientific Students’ Association 2nd place (Animal physiology)
    • Czimmermann Eszter: National Scientific Students’ Association 3rd place (Animal physiology)
    • Szombath Gergely: National Scientific Students’ Association 1st place (Animal health)
  • Supervision of PhD student:

Dr. Bús-Pomothy Judit; title of the PhD thesis: Use of potentially protective substances to maintain the integrity of the intestinal barrier damaged by mycotoxins in in vitro models (2022)

Further studies

  • 2002-2003 University of Michigan, Ann Arbor, MI, USA
    • neuropharmacological research on rat striatal slices
  • 2014 Philipps University, Marburg, Germany
    • synthesis of matriptase inhibitors, investigation of enzyme kinetics

Membership in Scientific Societies

2011- Hungarian Microbiological Society

Awards

  • 2014 Erdős Pál Research Fellowship National Excellence Programme
  • 2015 OTKA postdoctoral fellowship
  • 2015 Bolyai János Research Fellowship – Hungarian Academy of Sciences

 

Fundings

2014-2015 KK-UK Study on the effects of matriptase inhibitors on porcine intestinal cells
2015-2020 OTKA 115685 Xenobiotics-induced intestinal damage in swine

2016 KK-KF Preclinical Drug Development Research Group

2017-2022 OTKA 124522 The effects of probiotics and antioxidants on damage to porcine epithelial cells caused by veterinary pharmaceutical, toxic and infectious agents in vitro

 

Selected publications (Top10)

MTMT: https://m2.mtmt.hu/gui2/?type=authors&mode=browse&sel=authors10023380

1. Gamba D, van Eijk N, Lányi K, Monostory K, Steinmetzer T, Marosi A, Rácz A, Bajusz D, Kruhl D, Böttcher-Friebertshäuser E, Pászti-Gere E. PK/PD investigation of antiviral host matriptase/TMPRSS2 inhibitors in cell models. Sci Rep. 2024 Jul 18;14(1):16621. doi: 10.1038/s41598-024-67633-2.
2. Maluck S, Bobrovsky R, Poór M, Lange RW, Steinmetzer T, Jerzsele Á, Adorján A, Bajusz D, Rácz A, Pászti-Gere E. In Vitro Evaluation of Antipseudomonal Activity and Safety Profile of Peptidomimetic Furin Inhibitors. Biomedicines. 2024 Sep 11;12(9):2075. doi: 10.3390/biomedicines12092075.
3. van Niekerk AA, Maluck S, Mag P, Kővágó C, Kerek Á, Jerzsele Á, Steinmetzer T, Pászti-Gere E. Antiviral Drug Candidate Repositioning for Streptococcus suis Infection in Non-Tumorigenic Cell Models. Biomedicines. 2024 Apr 2;12(4):783. doi: 10.3390/biomedicines12040783.
4. Lányi K, Monostory K, Steinmetzer T, Jerzsele Á, Pászti-Gere E. In Vitro Pharmacokinetic Behavior of Antiviral 3-Amidinophenylalanine Derivatives in Rat, Dog and Monkey Hepatocytes. Biomedicines. 2023 Feb 23;11(3):682. doi: 10.3390/biomedicines11030682.
5. van Eijk N, Schmacke LC, Steinmetzer T, Pilgram O, Poór M, Pászti-Gere E. In vitro testing of host-targeting small molecule antiviral matriptase/TMPRSS2 inhibitors in 2D and 3D cell-based assays. Biomed Pharmacother. 2023 Dec;168:115761. doi: 10.1016/j.biopha.2023.115761. Epub 2023 Oct 20.
6. Fedor Z, Szentkirályi-Tóth A, Nagy G, Szimrók Z, Varga E, Pászti A, Pászti Z, Jerzsele Á, Pilgram O, Steinmetzer T, Mátis G, Neogrády Z, Pászti-Gere E. Interspecies Comparisons of the Effects of Potential Antiviral 3-Amidinophenylalanine Derivatives on Cytochrome P450 1A2 Isoenzyme. Vet Sci. 2022 Mar 23;9(4):156. doi: 10.3390/vetsci9040156.
7. Pászti-Gere E, Szentkirályi-Tóth A, Szabó P, Steinmetzer T, Fliszár-Nyúl E, Poór M. In vitro characterization of the furin inhibitor MI-1851: Albumin binding, interaction with cytochrome P450 enzymes and cytotoxicity. Biomed Pharmacother. 2022 Jul;151:113124. doi: 10.1016/j.biopha.2022.113124. Epub 2022 May 17.
8. Pászti-Gere E, Szentkirályi A, Fedor Z, Nagy G, Szimrók Z, Pászti Z, Pászti A, Pilgram O, Steinmetzer T, Bodnárová S, Fliszár-Nyúl E, Poór M. In vitro interaction of potential antiviral TMPRSS2 inhibitors with human serum albumin and cytochrome P 450 isoenzymes. Biomed Pharmacother. 2022 Feb;146:112513. doi: 10.1016/j.biopha.2021.112513. Epub 2021 Dec 13.
9. Wohlert A, Palkovicsné Pézsa N, Móritz AV, Jerzsele Á, Farkas O, Pászti-Gere E. Luteolin and Chrysin Could Prevent E. coli Lipopolysaccharide-Ochratoxin A Combination-Caused Inflammation and Oxidative Stress in In Vitro Porcine Intestinal Model. Animals (Basel). 2022 Oct 13;12(20):2747. doi: 10.3390/ani12202747.
10. Pászti-Gere E, Pomothy J, Jerzsele Á, Pilgram O, Steinmetzer T. Exposure of human intestinal epithelial cells and primary human hepatocytes to trypsin-like serine protease inhibitors with potential antiviral effect. J Enzyme Inhib Med Chem. 2021 Dec;36(1):659-668. doi: 10.1080/14756366.2021.1886093.

 

(Updated: January 2025)