Course description

During Veterinary Pharmacology 2, students learn the theoretical and practical aspects of the usage of etiotropic drugs involving antimicrobial, antiparasitic and antineoplastic agents. Similarly to the first semester, we aim to develop students’ first day skills of drug use and educate pharmacology based on the relevant scientific literature supplemented with ethical, legal and public health aspects. Significant part of the course is dedicated to the pharmacology of antibacterial agents, where strong emphasis is put on the prudent use of these drugs due to the spread of antimicrobial resistance in both human and veterinary medicine. Furthermore, during practicals, students learn to calculate drug doses to be administered for both individual and mass treatment, and they perform and evaluate a complex pharmacokinetic investigation on broiler chickens.

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Lectures theme

PHARMACOLOGY 2. LECTURE SCHEDULE Academic year 2023/2024, 2nd Semester Time of lectures: Monday 12:15-14:00 (Magyary-Kossa)
Date	Time	Lecture no.	Topic	Lecturer
5 February 2024	12:15-14:00	Lecture 1-2	Penicillins and other beta-lactam antibiotics	Ákos Jerzsele
12 February 2024	12:15-13:00	Lecture 3	Cefalosporins, Aminoglycosides	Ákos Jerzsele
19 February 2024	12:15-14:00	Lecture 5-6	Tetracyclines, Phenicols	Orsolya Farkas
26 February 2024	12:15-14:00	Lecture 7-8	Macrolides, lincosamides, pleuromutilins	Ákos Jerzsele
4 March 2024	12:15-14:00	Lecture 9-10	Fluoroquinolones and other antibacterial agents	Ákos Jerzsele
11 March 2024	12:15-14:00	Lecture 11-12	Polypeptides, rifamycins, glycopeptides Sulphonamides and diaminopyrimidines	Ákos Jerzsele
18 March 2024	12:15-14:00	Lecture 13-14	Anthelminthic agents I.	György Csikó
25 March 2024	12:15-14:00	Lecture 15-16	HOLIDAY ISSUED BY THE RECTOR	–
1 April 2024	12:15-14:00	Lecture 17-18	HOLIDAY ISSUED BY THE RECTOR	–
8 April 2024	12:15-13:00	Lecture 19	Anthelminthic agents II.	György Csikó
8 April 2024	13:15-14:00	Lecture 20	Ectoparasiticides I.	Ákos Jerzsele
15 April 2024	12:15-14:00	Lecture 21-22	Ectoparasiticides II.	Ákos Jerzsele
22 April 2024	12:15-14:00	Lecture 23-24	Anticoccidials and other antiprotozoal drugs	György Csikó
29 April 2024	12:15-14:00	Lecture 25-26	Disinfectants and antiseptics	Farkas Orsolya
6 May 2024	12:15-14:00	Lecture 27-28	Antifungal drugs	Erzsébet Gere
13 May 2024	12:15-14:00	Lecture 29-30	Antineoplastic and antiviral agents	Erzsébet Gere
Budapest, 31 January 2024
Ákos Jerzsele DVM Ph.D. Head of Department

Practical lessons theme

2nd Semester 2023/2024

Week 1 Feb. 05-09.	Introduction to chemotherapy
Week 2 Feb. 12-16.	Pharmacology of hormones
Week 3 Feb. 19-23.	Basic knowledge of pharmacokinetics Small test 1
Week 4 Feb 26-March 01	Ocular pharmacology
Week 5 March 04-08.	Drug development and authorization, Simulation exercises Small test 2
Week 6 March 11-15.	Midterm test 1 (13 March)
Week 7 March 18-22.	Usage of antibiotics in poultry and swine Midterm test 1 retake (20 March)
Week 8 March 25-29.	Holiday issued by the Rector
Week 9 Apr. 01-05.	Usage of antibiotics in ruminants and horses
Week 10 Apr. 08-12.	Usage of antibiotics in companion animals
Week 11 Apr. 15-19.	Usage of endoparasiticides I. – companion animals Small test 3
Week 12 Apr. 22-26.	Usage of endoparasiticides I. – farm animals
Week 13 Apr 29-May 03	Midterm test 2 (30 April)
Week 14 May 06-10.	Usage of ectoparasiticides Midterm test 2 retake (8 May)
Week 15 May 13-17.	Drug administration routes and examination of drug activity in rabbits Final retake test (15 May)

 

Practical group teachers

Group	Teacher
1.	Alma Móritz
2.	György Csikó
3.	Erzsébet Pásztiné Gere
4.	Mercédesz Adrienn Veres
5.	György Csikó
6.	Orsolya Farkas
7.	Mercédesz Adrienn Veres
8.	Melinda Nemes-Terényi
9.	Orsolya Palócz
10.	Erzsébet Pásztiné Gere

 

Budapest, 31 January 2024

 

Ákos Jerzsele DVM Ph.D.

Head of Department

Evaluation description

COURSE REQUIREMENTS

VETERINARY PHARMACOLOGY 2 in English, Spring semester, Academic year 2023/2024

 

1. For completing the semester the followings are required:

1. Regular visiting of the lectures
2. Successfully completing all practicals, including:
3. practicals can be missed not more than five times per semester, and all missed practicals must be retaken (the date and method of retake must be discussed with the practical group teacher)
4. changing group for the practicals is allowed two times per semester, but only upon previous agreement with the practical group teachers,
5. Passing the small tests: achieving at least an average of 70% on the small tests.
6. Passing the two midterm tests: achieving at least 70% on each midterm test.

The acceptance of the semester is certified by the signature of the authorized teacher. More than five weeks of absence in a semester results in an automatic exclusion from the semester (cf. Student’s guide).

2. Practicals

The attendance on all practicals is obligatory. The names of students will be checked by the practical group teacher, and in addition, students will prove their appearance with their signature. All missed practicals have to be retaken. Students should bring a lab coat to all practicals. It is prohibited to take pictures or record the practicals.

3. Tests during the semester

 At the beginning of some practicals, small tests will be written (their date is shown in the practical schedule). All small tests are obligatory and can be done only once (there will be no retake option). At least 70% should be achieved as an average of the small tests. In case of not achieving 70%, a final retake test will be provided at the end of the semester covering all practical topics of the semester (its date is shown in the practical schedule). If this is also failed, the student cannot get signature and cannot sign up for the exam.

Besides the small tests, two midterms will be written during the semester. Both midterms are obligatory, and one retake option will be provided for each. At least 70% should be achieved on both midterms for the signature. If the student cannot attend the midterm, it will be counted as a failed test. The only exception is if someone cannot attend the test due some other commitments related to their university studies, in which case an additional occasion can be provided for test writing.  In case someone fails or misses any of the midterms, a final retake midterm should be written at the end of the semester, covering topics of both midterms. If this is also failed, the student cannot get signature and cannot sign up for the final exam. The midterms’ date is shown in the practical schedule. During the midterm tests, students must place all their electronic devices (e.g. phones, tablets, smart watches) at a place where they are fully visible, and must not use them during test writing.

On the midterms’ weeks, there are no practicals.

Reviewing the midterm tests will be done as follows:

• in case of a failed midterm, students may review their test on the week of the midterm with their practical group teacher, upon discussing the dates separately with the teacher,
• in case of a passed midterm, students may review their test at the end of their next practical.

At the end of the semester, students must pass the final exam, which consists of a written and an oral part.

The written exam is obligatory. There are no consequences of 1 failed written exam, but after 2 unsuccessful written exams a fail (1) mark is applied. The oral exam can only be taken after successfully passing the written part. The written exam is successful in case of achieving at least 60%.

On the oral exam, two topics must be drawn by the students. For passing the exam, both topics must be known on a satisfactory level. The final grade will be based on the performance on the oral exam, result of the written part does not affect it. The oral exam cannot be successful without knowing the most important drug names marked on the drug list previously provided by the Department. All topics on the oral exam must be started with listing the relevant drug names, at least the marked, main substances. However, knowing these drug names alone is not enough for passing the oral exam!

In case of diseases, missing the oral exam can be accepted, but only if there is written notice to the Department not latest than on the day of the exam, and a medical certificate is provided in 5 working days.

If a successful written exam is followed by a failed oral exam, the written part doesn’t need to be repeated in the current semester. However, if the subject must be retaken in a later semesters, the written exam must also be repeated. Furthermore, starting from the 2022/23/2 semester, all previously passed written exams became invalid, regardless of their date. Therefore, all students (normal, retake and inactive) must start the final exam with the written part.

In case of general questions about education, please contact dr. Dóra Kovács (kovacs.dora@univet.hu).

Recommended literature:

Lecture slideshows (obligatory)

Dawn Boothe: Small Animal Clinical Pharmacology and Therapeutics

Donald C. Plumb: Plumb’s Veterinary Drug Handbook

Jim E. Riviere & Mark G. Papich: Veterinary Pharmacology and Therapeutics

Steeve Giguére: Antimicrobial Therapy in Veterinary Medicine

 

31 January 2024

 

Ákos Jerzsele DVM Ph.D.

Head of Department

Exam information

Pharmacology oral exam – general requirements

Template for discussing oral exam topics:

1.	The student must list drug groups and at least the most important active substances (written in bold in the drug list) included in the topic. Without listing the most important substances, the topic cannot be started, and the exam cannot be accepted. However, listing the substances without further knowledge of the topic is not enough for passing the exam. (See drug list for the substances needed to be known for the oral exam.)
For all aspects below, important differences between animal species must be known by the student (if it is applicable to the topic).
2.	The student must know information about chemical structure of the drug group, and if there are chemical structure based grouping of substances in the topic. Furthermore, if applicable, structure related pharmacological properties must be mentioned (e.g. beta lactam antibiotics, NSAIDs, glucocorticoids, fluoroquinolones structure – activity relationship).
3.	Mechanism of action. The student must know exact mechanism of action of the drugs belonging to the topic, including structure dependent and independent actions, molecular background of their effect, drug targets, agonist and antagonist effect, etc.
4.	In case of chemotherapeutics, the student must know their mode of action (bacteriostatic, time/concentration-dependent bactericidal).
5.	In case of chemotherapeutics, the student must know information about resistance to the drugs included in the topic, e.g. mechanisms and spread of resistance in different bacteria against the concerned substances.
6.	In case of chemotherapeutics, the student must know their antibacterial/antiviral/antifungal spectrum (see drug spectrum table).
7.	The student must know information about the pharmacokinetics of the drug group (including absorption, distribution, metabolism, excretion, and if applicable: enterohepatic recirculation, accumulation), and pharmacological consequences of these information, e.g. common routes, dose and frequency of administration. See dosage list for the doses to be known by heart.
8.	The student must know side effects of the drug group, and their consequences, if applicable, e.g. contraindications, drug interactions (e.g. aminoglycosides – muscle relaxants, tiamulin – monensin/narasin/salinomycin) and side effects that might be used as therapeutic indications (e.g. opioids as antitussives and antidiarrheals).
9.	The student must know indications of the active substances, i.e. for which therapeutic purposes are the drug groups and active substances used.

 

Topics of the pharmacology exam

Academic year 2023/2024

 Two topics must be drawn by students. For passing the exam, both topics must be known on a satisfactory level.

 

1. Mechanism of action of drugs: receptor- and non-receptor-mediated drug effects

2. Quantitative correlations of drug-receptor interactions, dissociation constant, quantal dose-response curve, efficacy, potency, therapeutic definitions, agonists, antagonists
3. Drug toxicity, drug side effects
4. Drug interactions and incompatibility
5. Factors influencing drug actions
6. Pharmacokinetics (absorption, distribution)
7. Pharmacokinetics (metabolism, elimination)
8. Pharmacokinetic calculations (compartmental and non- compartmental models), determination of the major pharmacokinetic parameters
9. Pharmacokinetic bases of pharmacotherapy (bioavailability, loading dose, maintenance dose)
10. Neuroleptics (major tranquilizers)
11. Sedato-hypnotics
12. Anticonvulsant agents
13. Antidepressants and behaviour modifying agents
14. Opioids
15. Central and peripheral muscle relaxants, smooth muscle relaxants
16. Local anaesthetics
17. Inhalational anaesthetics
18. Injectable anaesthetics
19. Parasympathomimetic and parasympatholytic agents
20. Sympathomimetics and sympatholytic agents
21. Nonsteroidal anti-inflammatory agents
22. Glucocorticoids
23. Pharmacology of immunosuppression
24. Antihistamines, leukotriene-receptor antagonists, Janus-kinase inhibitor, monoclonal antibodies (anti IL-31 and NGF) in the veterinary medicine
25. Pharmacology of the respiratory tract
26. Antiarrhythmic agents
27. Drugs improving cardiac contractility (cardiotonics)
28. ACE-inhibitors, angiotensin-receptor antagonists, vasodilators
29. Diuretics
30. Pharmacology of anaemia (iron, erythropoietin and derivative), hemostasis and thrombosis
31. Emetics, antiemetics, prokinetic agents
32. Antiulcer agents and liver protectants
33. Laxatives, antidiarrheals, appetite stimulants
34. Pharmacology of the drugs influencing sexual function 1. (GnRH and its analogues, gonadotropins, prostaglandins)
35. Pharmacology of the drugs influencing sexual function 2. (progestagens, oestrogens, androgens)
36. Pharmacology of the hypothalamic–pituitary hormones
37. Adrenocortical hormones, drugs for treatment of Cushing-disease and Addison-disease
38. Thyroid hormones, drugs for treatment of hypothyroidism and hyperthyroidism
39. Insulin and other antidiabetics
40. Uterus muscle stimulants and relaxants
41. Pharmacological basis of chemotherapy
42. Penicillins and beta-lactamase inhibitors
43. Cefalosporins, monobactams and carbapenems
44. Aminoglycosides
45. Tetracyclines
46. Macrolides
47. Phenicols, lincosamides and pleuromutilins
48. Polypeptides and other antibiotics (glycopeptides, rifamycins)
49. Sulphonamides and diaminopyrimidines
50. Fluoroquinolones, other antibacterial agents (nitroimidazoles, nitrofurans, fosfomycin)
51. Anticoccidial agents
52. Anti-protozoal agents (except coccidiosis)
53. Anthelmintics (benzimidazoles, imidazothiazoles, tetrahydropyrimidines)
54. Anthelmintics (salicylanilides, substituted phenols, isoquinolines, clorsulon, monepantel, emodepside)
55. Endectocidal macrocyclic lactones
56. Drugs against ectoparasites (except macrocyclic lactones) I. (organophosphates, carbamates, pyrethroids, amitraz)
57. Drugs against ectoparasites (except macrocyclic lactones) II. (phenylpyrazoles, neonicotinoids, isoxazolines, insect growth regulators)
58. Disinfectants 1. (halogens and halogen-containing compounds, acids, alkalies, alcohols)
59. Disinfectants 2. (aldehydes and alkylating agents, peroxides, surface-active compounds, phenols)
60. Antifungal agents
61. Antiviral agents
62. Antineoplastic agents
63. Usage of antibiotics in ruminants and horses
64. Usage of antibiotics in poultry and swine
65. Usage of antibiotics in companion animals
66. Fluid therapy

 

Budapest, 31^th January 2024

Ákos Jerzsele DVM Ph.D.

Head of department