RESEARCH GROUP LEADER: Dr. Bence RÁCZ PhD, professor
CONTACT: [Click to see email]
RESEARCH GROUP MEMBERS:
1) Dr. Tamás HORVÁTH
2) Prof. Dr. Péter SÓTONYI
3) Dr. Ferenc MÁTYÁS
4) Dr. Mátyás KAPILLER
5) Dr. Diána HAZAI
6) Dr. Katalin HALASY
RESEARCH TOPIC:
Synapses contain a complex biochemical machinery that supports and contributes to the proper functioning of synaptic signalling and plasticity. The research team aims to better understand the role of the cytoskeleton in the plasticity of neurons. We will perform molecular, biochemical and ultrastructural studies to elucidate how each synapse is built and functions, and the role of molecular organisation in regulating synapse formation, morphology, signalling and plasticity during normal and abnormal neuronal function.
TOP PUBLICATIONS:
1) Maglione, Marta ; Kochlamazashvili, Gaga ; Eisenberg, Tobias ; Rácz, Bence ; Michael, Eva ; Toppe, David ; Stumpf, Alexander ; Wirth, Alexander ; Zeug, André ; Müller, Franziska E et al. Spermidine protects from age-related synaptic alterations at hippocampal mossy fiber-CA3 synapses. SCIENTIFIC REPORTS 9 : 1 p. 19616 (2019)
2) Schroeder, Sabrina ; Hofer, Sebastian J. ; Zimmermann, Andreas ; Pechlaner, Raimund ; Dammbrueck, Christopher ; Pendl, Tobias ; Marcello, G. Mark ; Pogatschnigg, Viktoria ; Bergmann, Martina ; Müller, Melanie et al. Dietary spermidine improves cognitive function CELL REPORTS 35 : 2 Paper: 108985 (2021)
3) Gómez-Valadés, Alicia G. ; Pozo, Macarena ; Varela, Luis ; Boudjadja, Mehdi Boutagouga ; Ramírez, Sara ; Chivite, Iñigo ; Eyre, Elena ; Haddad-Tóvolli, Roberta ; Obri, Arnaud ; Milà-Guasch, Maria et al. Mitochondrial cristae-remodeling protein OPA1 in POMC neurons couples Ca2+ homeostasis with adipose tissue lipolysis CELL METABOLISM 33 : 9 pp. 1820-1835.e9. (2021)
4) Stutz, Bernardo ; Waterson, Michael J. ; Šestan-Peša, Matija ; Dietrich, Marcelo O. ; Škarica, Mario ; Sestan, Nenad ; Racz, Bence ; Magyar, Aletta ; Sotonyi, Peter ; Liu, Zhong-Wu et al. AgRP neurons control structure and function of the medial prefrontal cortex MOLECULAR PSYCHIATRY
5) Endle, Heiko ; Horta, Guilherme ; Stutz, Bernardo ; Muthuraman, Muthuraman ; Tegeder, Irmgard ; Schreiber, Yannick ; Snodgrass, Isabel Faria ; Gurke, Robert ; Liu, Zhong-Wu ; Sestan-Pesa, Matija et al. AgRP neurons control feeding behaviour at cortical synapses via peripherally derived lysophospholipids NATURE METABOLISM 4: 6 pp. 683-692., 10 p. (2022)
GRANT PROJECTS:
Hunger controls aging