RESEARCH GROUP LEADER: Dr. Márta LŐRINCZ PhD, senior lecturer

CONTACT: [Click to see email]

 

MEMBERS:

1) Dominik Ádám GULYÁS

2) Dóra FÖLDI

3) Éva SZÜCS-SOMLYÓ

 

RESEARCH TOPIC:

This team is looking for a solution to two seemingly independent problems. One option for treating tumor cells is based on the modification of the adaptive immune response. It is also advisable to change the effect of adjuvants used for conventional inactivated vaccines in the case of intracellular pathogens. Immunotherapy used in the case of tumors is developing at a rapid pace. The literature has reported many successful preclinical and clinical trials. The most important directions of research currently taking place in the field of immunotherapy are immune checkpoint inhibitors and adaptive cell therapies, which have proven the important role of the immune system in the treatment and eradication of tumors.
In veterinary medicine, mainly conventional vaccines are used widespread. Taking into account aspects of reliability, the use of inactivated vaccines is preferable, but their effectiveness is inferior to that of attenuated vaccines. The market is therefore currently receptive to new-generation vaccines that combine the safety of an inactivated immunogen with the efficacy of a live pathogen. During inactivation, viruses and intracellular pathogens lose their ability to enter the cells, so the cellular immune response becomes impossible.
Our research aims to study the effect of immunotherapy by manipulating the innate immune system and its effect on tumor growth and the development of metastases. In addition, in the case of inactivated vaccines, we want to achieve the activation of cytotoxic T cells during the treatments.

 

TOP PUBLICATIONS:

1) Gulyas D, Kovacs G, Jankovics I, Meszaros L, Lorincz M, Denes B (2022) Effects of the combination of a monoclonal agonistic mouse anti-OX40 antibody and toll-like receptor agonists: Unmethylated CpG and LPS on an MB49 bladder cancer cell line in a mouse model. PLoS ONE 17(7): e0270802.

 

GRANT PROJECTS:

1) National Laboratory of Infectious Animal Diseases, Antimicrobial Resistance, Veterinary Public Health and Food Chain Safety

2) Development of Novel Vaccine Adjuvant Formulation Against IBV for Poultry Industry

3) The use of natural immune response modulating substances in vaccine development