RESEARCH GROUP LEADER: Dr. Máté MACKEI PhD
CONTACT: [Click to see email]
MEMBERS:
1) Dr. Gábor MÁTIS
2) Dr. Zsuzsanna NEOGRÁDY
3) Dr. Csilla PAPP-SEBŐK
RESEARCH TOPIC:
The research areas of the group cover a wide range of studies on healthy and pathological metabolism in domestic animals. We are interested in studying the epigenetic and metabolic effects of different feed ingredients and feed supplements on various tissues, with particular emphasis on specific members of the insulin and glucagon signalling pathways and changes in the gut microbiome. Emphasis is placed on the function and modulation of cytochrome P450 enzymes, which play a key role in hepatic and intestinal detoxification processes, and comparative studies are performed in different farm and wild animal species. In addition, we investigate the effects of various xenobiotics and environmental stressors on the metabolism of domestic bees, especially concerning the effects of sublethal doses of pesticides on redox homeostasis and inflammatory response, and testing potential protective agents.
TOP PUBLICATIONS:
1) Mátis, Gábor; Mackei, Máté; Boomsma, Bart; Fébel, Hedvig; Nadolna, Katarzyna; Szymański, Łukasz; Edwards, Joan E.; Neogrády, Zsuzsanna; Kozłowski, Krzysztof: Dietary Protected Butyrate Supplementation of Broilers Modulates Intestinal Tight Junction Proteins and Stimulates Endogenous Production of Short Chain Fatty Acids in the Caecum ANIMALS 12 : 15 Paper: 1940 , 18 p. (2022)
2) Petrilla, Janka; Mátis, Gábor; Mackei, Máté; Kulcsár, Anna; Sebők, Csilla; Papp, Márton; Gálfi, Péter; Fébel, Hedvig; Huber, Korinna; Neogrády, Zsuzsanna: Modulation of Hepatic Insulin and Glucagon Signaling by Nutritional Factors in Broiler Chicken VETERINARY SCIENCES 9 : 3 Paper: 103 , 17 p. (2022)
3) Borda-Molina, Daniel; Matis, Gabor; Mackei, Mate; Neogrady, Zsuzsanna; Huber, Korinna; Seifert, Jana; Camarinha-Silva, Amelia: Caeca Microbial Variation in Broiler Chickens as a Result of Dietary Combinations Using Two Cereal Types, Supplementation of Crude Protein and Sodium Butyrate FRONTIERS IN MICROBIOLOGY 11 Paper: 617800 , 11 p. (2021)
4) Mackei, Máté; Mátis, Gábor; Molnár, Andor; Sebők, Csilla; Vörösházi, Júlia; Pál, László; Dublecz, Károly; Husvéth, Ferenc; Neogrády, Zsuzsanna: The relationship between small heat shock proteins and redox homeostasis during acute heat stress in chickens JOURNAL OF THERMAL BIOLOGY: ENVIRONMENT EVOLUTION AND MEDICINE 100 Paper: 103040 , 11 p. (2021)
5) Mackei, Máté; Talabér, Rebeka; Müller, Linda; Sterczer, Ágnes; Fébel, Hedvig; Neogrády, Zsuzsanna; Mátis, Gábor: Altered Intestinal Production of Volatile Fatty Acids in Dogs Triggered by Lactulose and Psyllium Treatment VETERINARY SCIENCES 9 : 5 Paper: 206 , 14 p. (2022)
GRANT PROJECTS:
Investigation of certain antimicrobial peptides in novel in vitro chicken and porcine gut-liver axis models