Intermediary metabolism: carbohydrates, amino acids, lipids. Biochemistry of different organs. Biochemistry of ruminants. Role of vitamins in the intermediary metabolism. Special focus on the veterinary clinical aspects of Biochemistry and the molecular basis of metabolic diseases.
Important note: All the PPT presentations as well as the video materials are aveilable in the Moodle page of the subject.
|Week 1||Respiratory chain, oxidative phosphorylation. Regulation of blood sugar level.||Dr. Mackei Máté|
|Week 2||Metabolism of other monosaccharides: fructose, galactose. Amino acid metabolism: transamination, oxidative deamination. Glucogenic, ketogenic, essential, non-essential amino acids.||Dr. Mackei Máté|
|Week 3||Detoxification of ammonia: urea cycle, ammonium ion formation. Decarboxylation of amino acids, biogenic amines. Biologically relevant peptides. Structure and function of hemoglobin.||Dr. Mackei Máté|
|Week 4||Porphyrine metabolism: synthesis and degradation. Myoglobin, catalase, peroxidase, cytochromes. Iron metabolism. Role and chemical structure of lipids. Absorption and transport of lipids.||Dr. Mackei Máté|
|Week 5||The lipolysis. Degradation of fatty acids: beta-oxidation of even-carbon, odd-carbon and unsaturated fatty acids. Ketogenesis, ketolysis. Biochemical background of ketosis.||Dr. Mátis Gábor|
|Week 6||Synthesis of even-carbon, odd-carbon and unsaturated fatty acids. Lipogenesis. Lipoids: phosphoglycerides, sphingolipids.||Dr. Mátis Gábor|
|Week 7||Steroids: structure and function of cholesterol. Synthesis of cholesterol. The metabolism of bile acids and steroid hormones.||Dr. Mackei Máté|
|Week 8||EASTER HOLIDAY, NO LECTURE|
|Week 9||Role of the liver: intermediary metabolism, secretion; detoxification: synthesis, oxidation, reduction, hydrolysis, conjugation. Biochemistry of muscle, brain, adipose tissue and kidney.||Dr. Neogrády Zsuzsanna|
|Week 10||Carbohydrate metabolism of ruminants: production of volatile fatty acids. Absorption and metabolism of the volatile fatty acids in the ruminants’ tissues. Metabolism of nitrogen-containing compounds in ruminants.||Dr. Neogrády Zsuzsanna|
|Week 11||Lipid metabolism of ruminants. Ketosis of the ruminants. Biochemistry of milk production. Introduction of vitamins.||Dr. Neogrády Zsuzsanna|
|Week 12||Biochemistry of retinol (vitamin A) and calcipherol (vitamin D). Biochemistry of tocopherol (vitamin E).||Dr. Neogrády Zsuzsanna|
|Week 13||Biochemistry of phylloquinon (vitamin K), essential fatty acids and thiamine (vitamin B1). Biochemistry of riboflavin (vitamin B2) and niacinamide (vitamin B3).||Dr. Neogrády Zsuzsanna|
|Week 14||Biochemistry of pantothenic acid (vitamin B5), pyridoxine (vitamin B6) and biotin (vitamin B7). Biochemistry of folic acid (vitamin B9).||Dr. Neogrády Zsuzsanna|
|Week 15||Biochemistry of cobalamin (vitamin B12) and ascorbic acid (vitamin C). Biochemistry of lipotropic factors.||Dr. Neogrády Zsuzsanna|
Practical lessons theme
Students are hereby informed that the order and dates of the laboratory practicals in Biochemistry II. are as follows:
|VI.||Biological oxidation||15-19 February
|29 March – 2 April|
|X.||Regulation of blood sugar level||3-7 May
|Make-up labs||17-18 May|
Labs VIII-X.: 17 May, start: 12.00 – 15.00
Labs VI-VII.: 18 May, start: 12.00 – 15.00
According to the current Covid-19 measures, until further notice, the practicals are given online with videos uploaded to the Moodle system. An online test (comprised of 10 single choice questions) will be written from the subject of each practical on Friday of the appropriate practical weeks from 18.30 till 19.00 CET in the Neptun Unipoll system.
Dr. Csilla Sebők (E-mail: Sebok.Csilla@univet.hu) is responsible for the biochemical labs in English.
BIOCHEMISTRY II. in English
Students will be hereby informed that the prevalent qualification system and requirements in subject Biochemistry II. for the spring semester are as follows:
- Regular (online) visiting of the lectures
- Successful performance of all practicals
- Completion of 60% of the maximal scores in the practicals
- Completion of 60% of the maximal scores on the written midterm test
The complete qualification system of the subject can be downloaded from the webpage of the Department.
The date of the midterm test: 14 April 2021 at 7.15.
Retake of the midterm: 5 May 2021 at 7.15.
Extra retake (from whole Biochemistry II): 21 May 2021 at 7.15.
Consultation possibility: online, after registration (E-mail: Neogrady.Zsuzsanna@univet.hu)
Please note that the schedules and regulations of the Biochemistry II. course might be modified during the semester due to the Covid-19 pandemic.
Attending the Biochemistry 2. course:
Biochemistry 2. lectures and laboratory practicals can be visited and the Biochemistry 2. midterm can be written even without having Biochemistry 1. accepted. It means that completing the requirements of Biochemistry 1. is not a prerequisite of registering and attending the Biochemistry 2. course. However, attending the Biochemistry final exam (written and oral) is only possible after successful completion of all requirements of both Biochemistry 1. and 2. courses.
Requirements of the acceptance of the semester:
- Fulfilling the requirements of the theoretical part of Biochemistry 2.:
- Regular visiting of the lectures (no more than 3 unjustified absences can be accepted).
- Completion of 60% (18 points) of the maximal scores (30 points) on the written midterm test or midterm retake. If midterm retake is failed, the semester can be accepted if the student gets min. 18 points (60%) on the end-term examination at the end of the semester.
- Fulfilling the requirements of the practical part of Biochemistry 2.:
- Successful performance of all laboratory courses.
- Completion of 60% (15 points) of the maximal scores (25 points) in the laboratory courses.
If the written midterm test (or the midterm retake or the end-term examination) has not been completed, but the requirements of the practical part of Biochemistry 2. have been fulfilled, the semester is not accepted; however, only the midterm has to be repeated during a later semester. If the requirements of the practical part of Biochemistry 2. have not been fulfilled, but the written midterm test (or the midterm retake or the end-term examination) has been completed successfully, the semester is not accepted; however, only the practical part has to be repeated during a later semester.
- 51 – 55 points: excellent (5)
- 45 – 50 points: good (4)
- 40 – 44 points: medium (3)
- 33 – 39 points: satisfactory (2)
- 0 – 32 points: unsatisfactory (1)
It means that the theoretical (lectures, midterm) and practical (laboratory practicals) parts of Biochemistry 2. can be completed independently from each others. But please note that Biochemistry 2. labs will be held only in the spring semester of each academic year, but Biochemistry 2. midterm will be held both in the spring and fall semesters of each academic year.
It should be also regarded that attending the Biochemistry final exam (written and oral) is only possible after successful completion of all requirements of both Biochemistry 1. and 2. courses.
Evaluation system at the end of the Biochemistry 2. course:
Upon acceptance of the Biochemistry 2. semester, a signature is being given. Studying Biochemistry ends with a final examination (6 credits). Requirements of taking part on the final exam are the successful completion of all requirements of both Biochemistry 1. and 2. courses and successful completion of Chemistry (fall semester) and Veterinary and Food Chemistry (spring semester) exams.