The effect of drugs (good and bad) is basically determined by the disposition within the body, i.e. the extent of distribution in biological media and elimination from the biological spaces. From pharmacokinetic point of view, there is wide diversity in the case of some species. This may be important in the development of beneficial and harmful effects of drugs in different animal species. For food-producing species other important aspect is that the pharmacokinetic effects may alter the clearance of drugs from products with animal origin intended for human consumption. The subject is designed to provide advanced and detailed knowledge to the topic, thus promoting the practice more effective and side effect-free use of medicines, and encourage the production of residue-free food.
|Date and time||Topics|
|Introduction, basic knowledge on pharmacokinetics and drug residues. The effects of genetics, age and health on the drug disposition in living organisms. Drug interactions.|
|Testing methods of pharmacokinetics and drug-metabolism (in vivo, in vitro). Statistical analysis on pharmacokinetics and drug elimination.|
|Differences in pharmacokinetics and drug metabolism in food-producing and companion animal species.
Differences in pharmacokinetics and drug metabolism in exotic animals and bird species.
|will be determined later||Consultations, written test|
Lecture hall: will be given later, 3×45 min. without break
– Attendance on lectures is obligatory, however student may miss max. 30% of lectures (one occasion), if it is indicated (e.g. illness, official program of university).
– There is a written examination at the end of course. When retake of examination is necessary, the general education rules of the campus should be considered.