Welcome

KKP “Élvonal” Forefront Research Group

 

 

Tremendous scientific progress in modern medicine and hygiene over the last century has helped solve common causes of human mortality. These developments however have also revealed a plethora of new problems, such as chronic diseases as a result of aging. Age is the single biggest risk factor for diseases. Nevertheless, the biomedical research enterprise all around the world spends the equivalent of billions of euros every year to tackle each chronic disease separately. This disease-focused approach has unquestionably produced new treatments, however, longevity has come with a disability, where management of one age‐related chronic disease has been traded with the emergence of another. Calorie restriction benefits health and extends lifespan in all species so far studied. The goal of our proposal is to develop a mechanistic understanding of how calorie restriction benefits health- and life-span mediated by the brain with the long-term goal to develop mimic calorie restriction without its undesirable side effects, such as constant hunger and related stress.