RESEARCH GROUP LEADER: Dr. Orsolya FARKAS PhD, senior research fellow
CONTACT: [Click to see email]
MEMBERS:
1) Dr. Erzsébet PÁSZTINÉ GERE
2) Dr. Dóra KOVÁCS
3) Dr. Zita KARANCSI
4) Dr. Nikolett Dr. PALKOVICSNÉ PÉZSA
5) Dr. Alma Virág MÓRITZ
RESEARCH TOPIC:
The aim of the research is to develop in vitro cell culture models, to characterize pathological conditions induced by oxidative stress and inflammation caused by bacteria and xenobiotics, and to investigate the positive (anti-inflammatory, antioxidant, barrier-enhancing, antibacterial, etc.) effects of alternative dietary and feed supplements (e.g. probiotics, plant-derived compounds) on the models. We contribute to reducing animal testing in the context of the 3Rs principle by using models from different animal species, both companion and farm animals, representing their digestive tract and immune system. We also contribute to the maintenance of animal health and the reduction of antibiotic use and antimicrobial resistance, by testing alternatives of natural origin and by exploring the mechanisms underlying the positive effects.
TOP PUBLICATIONS:
1) Karancsi, Z. ; Kovacs, D. ; Pezsa, N. Palkovicsne ; Galfi, P. ; Jerzsele, A. ; Farkas, O. The Impact of Quercetin and Its Methylated Derivatives 3-o-Methylquercetin and Rhamnazin in Lipopolysaccharide-Induced Inflammation in Porcine Intestinal Cells ANTIOXIDANTS 11 : 7 Paper: 1265 , 12 p. (2022) Q1 (Clinical Biochemistry)
2) Palkovicsné, Pézsa N. ; Kovács, D. ; Gálfi, P. ; Rácz, B. ; Farkas, O. Effect of Enterococcus faecium NCIMB 10415 on Gut Barrier Function, Internal Redox State, Proinflammatory Response and Pathogen Inhibition Properties in Porcine Intestinal Epithelial Cells
NUTRIENTS 14 : 7 Paper: 1486 , 18 p. (2022) Q1 (Food Science)
3) Wohlert, A.; Palkovicsné Pézsa, N. ; Móritz, AV. ; Jerzsele, Á. ; Farkas, O. ; Pászti-Gere, E. Luteolin and Chrysin Could Prevent E. coli Lipopolysaccharide-Ochratoxin A Combination-Caused Inflammation and Oxidative Stress in In Vitro Porcine Intestinal Model ANIMALS 12 : 20 Paper: 2747 (2022) Q1 (Veterinary)
4) Kovács, D. ; Palkovicsné Pézsa, N. ; Jerzsele, Á. ; Süth, M. ; Farkas, O. Protective Effects of Grape Seed Oligomeric Proanthocyanidins in IPEC-J2–Escherichia coli/Salmonella Typhimurium Co-Culture ANTIBIOTICS 11 : 1 Paper: 110 (2022) Q1 (Pharmacology, Toxicology and Pharmaceutics )
5) Z., Karancsi ; A. V., Móritz ; N., Lewin ; A. M., Veres ; Á., Jerzsele ; O., Farkas Beneficial Effect of a Fermented Wheat Germ Extract in Intestinal Epithelial Cells in case of Lipopolysaccharide-Evoked Inflammation OXIDATIVE MEDICINE AND CELLULAR LONGEVITY 2020 Paper: 1482482 (2020) Q1 (Biochemistry)