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Research Research teams Preclinical Drug Development Research Group

Preclinical Drug Development Research Group

RESEARCH GROUP LEADER: Dr. Erzsébet PÁSZTINÉ GERE PhD, PharmD, senior research associate

CONTACT: [Click to see email]



1) Dr. Ádám BÁLINT

2) Dr. Orsolya FARKAS

3) Dr. Katalin LÁNYI

4) Dr. Csaba KŐVÁGÓ

5) Dr. Orsolya PALÓCZ

6) Dr. Ádám KEREK

7) Dr. Patrik MAG

8) Zoltán SZIMRÓK



The aims of the research are characterization of newly prepared drug candidates, efficay studies in animal and in human cell models using 2 D and 3 D spheroid-, hydrogel-based methods, GI and hepatic side effects’ monitoring, mapping of antibacterial and antiviral effects of the compounds, activity measurements of CYP450 isoenzymes in microsomes and in hepatocytes of different animal species. Due to the cytotoxicity assays, safety profiles of the compounds can be evaluated prior to in vivo research. In vitro PD/PK studies also enable pharmakokinetic evaluation of the drug candidates obtained from drug repositioning or after chemical synthesis and at the same time they can lower the number of animal experiments.



1) Pászti-Gere, Erzsébet ; Szentkirályi-Tóth, Anna ; Szabó, Pál ; Steinmetzer, Torsten ; Fliszár-Nyúl, Eszter ; Poór, Miklós In vitro characterization of the furin inhibitor MI-1851: Albumin binding, interaction with cytochrome P450 enzymes and cytotoxicity BIOMEDICINE & PHARMACOTHERAPY 151 Paper: 113124 , 8 p. (2022) Q1 (Pharmacology)

2) Pászti-Gere, Erzsébet; Szentkirályi, Anna ; Fedor, Zsófia ; Nagy, Gábor ; Szimrók, Zoltán ; Pászti, Zoltán ; Pászti, Anna ; Pilgram, Oliver ; Steinmetzer, Torsten ; et al. In vitro interaction of potential antiviral TMPRSS2 inhibitors with human serum albumin and cytochrome P 450 isoenzymes BIOMEDICINE & PHARMACOTHERAPY 146 Paper: 112513 , 8 p. (2022) Q1 (Pharmacology)

3) Wohlert, A.; Palkovicsné Pézsa, N. ; Móritz, AV. ; Jerzsele, Á. ; Farkas, O. ; Pászti-Gere, E. Luteolin and Chrysin Could Prevent E. coli Lipopolysaccharide-Ochratoxin A Combination-Caused Inflammation and Oxidative Stress in In Vitro Porcine Intestinal Model ANIMALS 12 : 20 Paper: 2747 (2022) Q1 (Veterinary)

4) Pomothy, Judit Mercédesz ; Pászti-Gere, Erzsébet* ; Barna, Réka Fanni ; Prokoly, Dorottya ; Jerzsele, Ákos
The Impact of Fermented Wheat Germ Extract on Porcine Epithelial Cell Line Exposed to Deoxynivalenol and T-2 Mycotoxins OXIDATIVE MEDICINE AND CELLULAR LONGEVITY 2020 : Special Issue Paper: 3854247 , 9 p. (2020) Q1 (Biochemistry)

5) Karancsi, Z. ; Kovacs, D. ; Pezsa, N. Palkovicsne ; Galfi, P. ; Jerzsele, A. ; Farkas, O. The Impact of Quercetin and Its Methylated Derivatives 3-o-Methylquercetin and Rhamnazin in Lipopolysaccharide-Induced Inflammation in Porcine Intestinal Cells ANTIOXIDANTS 11 : 7 Paper: 1265 , 12 p. (2022) Q1 (Clinical Biochemistry)



1) The effects of probiotics and antioxidants on damage to porcine epithelial cells caused by veterinary pharmaceutical, toxic and infectious agents in vitro.

2) Development of a novel veterinary medicinal product for the inhibition of antibiotic resistance, development of a supporting drug repositioning platform.