University of Veterinary Medicine Budapest

university of Veterinary medicine budapest

Bioinformatics Research Group

RESEARCH GROUP LEADER: Norbert Solymosi

RESEARCH GROUP MEMBERS:

Full professor: István Csabai (Department of Physics of Complex Systems), Róbert Farkas, Zoltán Szállási (Computational Health Informatics Program (CHIP), Boston Children’s Hospital, Boston, MA, USA)

Associate professor: László Makrai, Norbert Solymosi

Senior lecturer: Ákos Maróti-Agóts

Research fellow: Sándor Spisák (Harvard Medical School, Dana Farber Cancer Institute, Medical Oncology Department), Gábor Valcz (Molecular Gastroenterology Laboratory, 2nd Department of Internal Medicine, Semmelweis University)

Assistant: –

PhD student: András Adorján

RESEARCH AREAS:

We work on the processing, analysis of datasets are generated by different throughput bioinformatical technologies. By the digital image analyis we support researches in quantitative bacteorology and pathology. Based on gene expression microarray datasets we perform biomarker identification and system biology analyses. For different research purposes (e.g. microbiome, polymorphism, methilation pattern) we do next generation sequencing data analyses.

MEMBERSHIPS:

LONG-TERM COLLABORATIONS:

Department of Endocrine Neurobiology, Institute of Experimental Medicine of Hungarian Academy of Sciences
Department of Physics of Complex Systems, Eötvös Lóránd University
II. Belgyógyászati Tanszék és Klinika, Molekuláris Gasztroenterológiai Laboratórium, Semmelweis Egyetem
Harvard Medical School, Dana Farber Cancer Institute, Medical Oncology

SERVICES:

quantitative digital image analysis
analysis of gene expression microarray data
analysis of NGS data

GRANTS: –

Támogató szervezet /forrás megnevezése	Pályázati projekt címe és témája (röviden)	Támogatás összege (Ft-ban)
EU H2020	COMPARE is a multidisciplinary research network that has the common vision to become the enabling analytical framework and globally linked data and information sharing platform for the rapid identification, containment and mitigation of emerging infectious diseases and foodborne outbreaks. (http://www.compare-europe.eu/)	6400,000,000 (20000000 €)

CONTRACTS: –

Additional information on the research services

results achieved so far, presentation of relevant references (grants and contracts)

Bodor A, Csabai I, Mahoney M W, Solymosi N. rCUR: an R package for CUR matrix decomposition. BMC BIOINFORMATICS 13:(1) Paper 103. 6 p. (2012)
Galamb O, Győrffy B, Sipos F, Dinya E, Krenács T, Berczi L, Szőke D, Spisák S, Solymosi N, Németh AM, Juhász M, Molnár B, Tulassay Z. Helicobacter pylori and antrum erosion-specific gene expression patterns: The discriminative role of CXCL13 and VCAM1 transcripts. HELICOBACTER 13:(2) pp. 112-126. (2008)
Galamb O, Sipos F, Solymosi N, Spisák S, Krenács T, Tóth K, Tulassay ZS, Molnár B. Diagnostic mRNA expression patterns of inflamed, benign, and malignant colorectal biopsy specimen and their correlation with peripheral blood results. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION 17:(10) pp. 2835-2845. (2008)
Galamb O, Spisák S, Sipos F, Tóth K, Solymosi N, Wichmann B, Krenács T, Valcz G, Tulassay ZS, Molnár B. Reversal of gene expression changes in the colorectal normal-adenoma pathway by NS398 selective COX2 inhibitor. BRITISH JOURNAL OF CANCER 102:(4) pp. 765-773. (2010)
Jalan S, Solymosi N, Vattay G, Li BW. Random matrix analysis of localization properties of gene coexpression network. PHYSICAL REVIEW E – STATISTICAL, NONLINEAR AND SOFT MATTER PHYSICS 81:(4) p. 046118. (2010)
Sárvári M, Hrabovszky E, Kalló I, Galamb O, Solymosi N, Liko I, Molnár B, Tihanyi K, Szombathelyi Z, Liposits Z. Gene expression profiling identifies key estradiol targets in the frontal cortex of the rat. ENDOCRINOLOGY 151:(3) pp. 1161-1176. (2010)
Sárvári M, Hrabovszky E, Kalló I, Solymosi N, Liko I, Berchtold N, Cotman C, Liposits Z. Menopause leads to elevated expression of macrophage-associated genes in the aging frontal cortex: rat and human studies identify strikingly similar changes. JOURNAL OF NEUROINFLAMMATION 9:(1) p. 264. (2012)
Sárvári M, Hrabovszky E, Kalló I, Solymosi N, Tóth K, Liko I, Szeles J, Maho S, Molnár B, Liposits Z. Estrogens regulate neuroinflammatory genes via estrogen receptors alpha and beta in the frontal cortex of middle-aged female rats. JOURNAL OF NEUROINFLAMMATION 8:(1) p. 82. (2011)
Sárvári M, Kalló I, Hrabovszky E, Solymosi N, Liposits Z. Ovariectomy Alters Gene Expression of the Hippocampal Formation in Middle-Aged Rats. ENDOCRINOLOGY (közlésre elfogadva) (2016)
Sárvári M, Kalló I, Hrabovszky E, Solymosi N, Liposits Z. Ovariectomy and subsequent treatment with estrogen receptor agonists tune the innate immune system of the hippocampus in middle-aged female rats. PLOS ONE 9:(2) p. e88540. (2014)
Sárvári M, Kalló I, Hrabovszky E, Solymosi N, Rodolosse A, Liposits Z. Long-Term Estrogen Receptor Beta Agonist Treatment Modifies the Hippocampal Transcriptome in Middle-Aged Ovariectomized Rats. FRONTIERS IN CELLULAR NEUROSCIENCE 10: p. 149. (2016)
Sárvári M, Kalló I, Hrabovszky E, Solymosi N, Rodolosse A, Vastagh C, Auer H, Liposits Z. Hippocampal Gene Expression Is Highly Responsive to Estradiol Replacement in Middle-Aged Female Rats. ENDOCRINOLOGY 156:(7) pp. 2632-2645. (2015)
Sárvári M, Kalló I, Hrabovszky E, Solymosi N, Tóth K, Liko I, Molnár B, Tihanyi K, Liposits Z. Estradiol Replacement Alters Expression of Genes Related to Neurotransmission and Immune Surveillance in the Frontal Cortex of Middle-Aged, Ovariectomized Rats. ENDOCRINOLOGY 151:(8) pp. 3847-3862. (2010)
Spisák S, Galamb B, Sipos F, Galamb O, Wichmann B, Solymosi N, Nemes B, Molnár J, Tulassay ZS, Molnár B. Applicability of antibody and mRNA expression microarrays for identifying diagnostic and progression markers of early and late stage colorectal cancer. DISEASE MARKERS 28:(1) pp. 1-14. (2010)
Spisák Sándor, Kate Lawrenson, Yanfang Fu, István Csabai, Rebecca T Cottman, Ji-Heui Seo, Christopher Haiman, Ying Han, Romina Lenci, Qiyuan Li, Viktória Tisza, Zoltán Szállási, Zachery T Herbert, Matthew Chabot, Mark Pomerantz, Norbert Solymosi, The GAME-ON/ELLIPSE Consortium, Simon A Gayther, J Keith Joung, Matthew L Freedman. CAUSEL: an epigenome- and genome-editing pipeline for establishing function of noncoding GWAS variants. NATURE MEDICINE 2015: pp. 1357-1363. (2015)
Spisák Sándor, Solymosi Norbert, Ittzés Péter, Bodor András, Kondor Dániel, Vattay Gábor, Barták K Barbara, Sipos Ferenc, Galamb Orsolya, Tulassay Zsolt, Szállási Zoltán, Rasmussen Simon, Sicheritz-Ponten Thomas, Brunak Sören, Molnár Béla, Csabai István. Complete genes may pass from food to human blood. PLOS ONE 8:(7) Paper e69805. 11 p. (2013)
Szőke D, Molnár B, Solymosi N, Klausz G, Gyulai ZS, Tóth B, Mándi Y, Tulassay ZS. T251a polymorphism of il-8 relating to the development of histological gastritis and g-308a polymorphism of tnf-[alpha] relating to the development of macroscopic erosion. EUROPEAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 20:(3) pp. 191-196. (2008)
Szőke D, Molnár B, Solymosi N, Rácz K, Gergics P, Blasko B, Vásárhelyi B, Vannay A, Mándy Y, Klausz G, Gyulai Zs, Galamb O, Spisák S, Hutkai B, Somogyi A, Berta K, Szabó A, Tulassay T, Tulassay Zs. Polymorphisms of the ApoE, HSD3B1, IL-1 beta and p53 genes are associated with the development of early uremic complications in diabetic patients: Results of a DNA resequencing array study. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 23:(2) pp. 217-227. (2009)
Szőke D, Molnár B, Solymosi N, Sipos F, Galamb O, Győrffy A, Tulassay Z. The RR genotype of codon 72 of p53 gene reduces the development of intestinal metaplasia. DIGESTIVE AND LIVER DISEASE 41:(3) pp. 179-184. (2009)
Vastagh C, Rodolosse A, Solymosi N, Farkas I, Auer H, Sárvári M, Liposits Z. Differential Gene Expression in Gonadotropin-Releasing Hormone Neurons of Male and Metestrous Female Mice. NEUROENDOCRINOLOGY 102:(1-2) pp. 44-59. (2015)
Vastagh C, Rodolosse A, Solymosi N, Liposits Z. Altered Expression of Genes Encoding Neurotransmitter Receptors in GnRH Neurons of Proestrous Mice. FRONTIERS IN CELLULAR NEUROSCIENCE 10: p. 230. (2016)