RESEARCH GROUP LEADER: Dr. Tibor BARTHA PhD, professor
CONTACT: [Click to see email]
MEMBERS:
1) Dr. Dávid Sándor KISS
2) Dr. István TÓTH
3) Dr. Gergely JÓCSÁK
4) Dr. Krisztián NÉMETH
5) Dr. Daiana ALYMBAEVA
RESEARCH TOPIC:
The main line of our research is built around investigating mechanisms and phenomena involved in the central control of homeostatic processes. Within this frame, we examine how hypothalamic integration of endocrine and neuroendocrine regulatory processes occurs as a result of peripheral factors and inputs from higher brain areas. Among these processes, our major interest, on one hand, focuses on the regulation of reproductive function, metabolic processes, and that of circadian rhythm. On the other hand, we also examine how pathological consequences are developed by mean of external adverse effects (endocrine disruptors, metal oxides, etc.) and pathological events (e.g. hepatic encephalopathy, Azlheimer’s disease, obesity, etc.). Our investigations (both in terms of the central nervous system or other tissues) are mainly carried out by examining cell populations, or cellular and intracellular processes (mitochondrial metabolism, receptor expressions, proteomics, inflammatory processes, cell-cell interactions, tissue integrity, etc.) applying mainly molecular and imaging techniques.
TOP PUBLICATIONS:
1) Zsarnovszky A., Kiss DS., Jocsak G., Nemeth G.; Toth I., Horvath TL.: Thyroid hormone- and estrogen receptor interactions with natural ligands and endocrine disruptors in the cerebellum, Frontiers in Neuroendocrinology, 48:23-36, 2018.
2) Kiss DS., Ioja E., Toth I., Barany Z., Jocsak G., Bartha T., Horvath TL., Zsarnovszky A.: Comparative analysis of zearalenone effects on thyroid receptor alpha (TRα) and beta (TRβ) expression in rat primary cerebellar cell cultures, International Journal of Molecular Sciences, 19(5). pii: E1440. 2018.
3) Jocsak G., Ioja E, Kiss DS., Toth I., Barany Z., Bartha T., Frenyo VL., Zsarnovszky A.: Endocrine Disruptors Induced Distinct Expression of Thyroid and Estrogen Receptors in Rat versus Mouse Primary Cerebellar Cell Cultures, Brain Sci., 9(12): 359, 2019.
4) Kiss DS., Toth I., Jocsak G., Bartha T., Frenyo VL., Barany Z., Horvath TL., Zsarnovszky A.: Metabolic lateralization in the hypothalamus of male rats related to reproductive and satiety states. Reprod Sci., 27(5): 1197–1205, 2020.
5) Kiss DS., Toth I., Jocsak G., Barany Z., Barha T., Frenyo VL., Horvath TL., Zsarnovszky A..: Functional aspects of hypothalamic asymmetry. Brain Sci., 10(6): 389