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Research Research teams Neurophysiology, Neuromorphology Research Group

Neurophysiology, Neuromorphology Research Group

RESEARCH GROUP LEADER: Dr. David Sandor Kiss, PhD

CONTACT: kiss.david@univet.hu

RESEARCH GROUP MEMBERS:

Associate professor: Dr. Attila Zsarnovszky

Assistant professor: Dr. Dávid Sándor Kiss

Assistant lecturer: Dr. István Tóth

Assistant research fellow: Dr. Gergely Jócsák

Assistants: Zsuzsanna Kinálné Szikora, László Ákos, Ildikó Horváth

PhD student: Dr. Zoltán Bárány

 

RESEARCH AREAS:

hypothalamic regulation of reproductive mechanisms, food-intake, and circadian rhythms

integration of hypothalamic information processing on neuronal and subcellular level

role of neuronal energy expenditure and synaptic plasticity in the hypothalamic control of the physiological mechanisms

 

Recent results:

We found a novel regulatory mechanism in the hypothalamus through examining the ATP hydrolyzing activity of NTPDase3 enzyme. We provided remarkable evidence on functional asymmetry in the neuroendocrine hypothalamus related to the estrous cycle. Our preliminary data also indicate that this functional asymmetry might affect other regulatory centers of physiological processes in the hypothalamus.

Available equipment:

  • electron microscope (together with other research groups)
  • fluorescent microscope
  • vibratome for tissue preparation/slicing
  • oxygen electrode for mitochondrial measurements, bench top centrifuges
  • equipment for subcellular fractionation
  • ELISA plate reader for quantitative protein/enzyme/hormone/etc. measurements
  • PCR equipment
  • Nanodrop for RNA, DNA and protein measurements
  • thermostat and laminar box for cell cultures
  • animal house (for rodents and rabbit)

 

MEMBERSHIPS:

Hungarian Physiological Society (MÉT)

Hungarian Society of Animal Protection and Animal Walfare (MÁÁT)

Hungarian Neuroscience Society

Research and Technological Innovation Council

 

LONG-TERM COLLABORATIONS:

Yale University, Connecticut, USA

University of Veterinary Medicine Hannover, Germany

Hohenheim University Stuttgart, Germany

Eötvös Loránd University, Hungary

Semmelweis University, Hungary

University of Oxford, MRC, UK

University of Kaposvár, Hungary

Purdue University, Indiana, USA

 

GRANTS:

Funding source

Project title and topic (date)

Amount (HUF)

OTKA 81745 National Research, Development and Innovation Office, Hungary (NRDIO)

Regulation of neuronal energy levels in the hypothalamus: NTPDases as possible energy

regulators of the positive gonadotrophin feedback

 19.938.000

 

NKB 15971

 

Preparation of purified mitochondrial fractions from relatively small hypothalamic brain samples

200.000 

NKB 15739

 

Hypothalamic sidedness in mitochondrial respiration: rediscovering decade-old observations and creating new perspectives.

301.000

Research Faculty

(Ministry of Human Capacities)

Hypothalamic sidedness: the main neuroendocrine centre from a new aspect (2013)

2.000.000

NKB TI 15930

 

Determination of region-specificity of mitochondrial metabolism according to distinct hypothalamic functions

737.000

OTKA 115613 National Research, Development and Innovation Office, Hungary (NRDIO)

Mitochondrial dynamics mediate endocrine disruptors' impact on nuclear receptors

53.785.000

Research Faculty

(Ministry of Human Capacities)

Functional asymmetry of the hypothalamus in male rats (2016)

1.500.000

Research Faculty

(Ministry of Human Capacities)

Establishment and characterization of primary hypothalamic cell cultures from mice (2016)

1.500.000